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Spleen Weight in Rats During Tumour Growth and in Homograft Rejection

The spleens of rats bearing methylcholanthrene induced sarcomas are enlarged. This applies both to primary and to isotransplanted tumours. The spleen enlarges with increasing tumour size. Splenomegaly is induced by skin homograft rejection, but spleen sizes do not reach those seen during tumour grow...

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Detalles Bibliográficos
Autores principales: Blamey, R. W., Evans, D. M. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1971
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008742/
https://www.ncbi.nlm.nih.gov/pubmed/4947347
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author Blamey, R. W.
Evans, D. M. D.
author_facet Blamey, R. W.
Evans, D. M. D.
author_sort Blamey, R. W.
collection PubMed
description The spleens of rats bearing methylcholanthrene induced sarcomas are enlarged. This applies both to primary and to isotransplanted tumours. The spleen enlarges with increasing tumour size. Splenomegaly is induced by skin homograft rejection, but spleen sizes do not reach those seen during tumour growth, even when the animals are chronically exposed to homologous skin. Sensitization of animals with small tumour homografts gives spleen sizes even greater than those of primary tumour growth. Spleen histology in tumour bearing animals is comparable with that of homograft rejection. The relation of splenomegaly to the presence of tumour specific antigen is discussed. The suggestion is advanced that the spleen size during tumour growth is determined by the product of reaction to foreign antigen, and of reticuloendothelial (phagocytic) activity.
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spelling pubmed-20087422009-09-10 Spleen Weight in Rats During Tumour Growth and in Homograft Rejection Blamey, R. W. Evans, D. M. D. Br J Cancer Articles The spleens of rats bearing methylcholanthrene induced sarcomas are enlarged. This applies both to primary and to isotransplanted tumours. The spleen enlarges with increasing tumour size. Splenomegaly is induced by skin homograft rejection, but spleen sizes do not reach those seen during tumour growth, even when the animals are chronically exposed to homologous skin. Sensitization of animals with small tumour homografts gives spleen sizes even greater than those of primary tumour growth. Spleen histology in tumour bearing animals is comparable with that of homograft rejection. The relation of splenomegaly to the presence of tumour specific antigen is discussed. The suggestion is advanced that the spleen size during tumour growth is determined by the product of reaction to foreign antigen, and of reticuloendothelial (phagocytic) activity. Nature Publishing Group 1971-09 /pmc/articles/PMC2008742/ /pubmed/4947347 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Blamey, R. W.
Evans, D. M. D.
Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title_full Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title_fullStr Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title_full_unstemmed Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title_short Spleen Weight in Rats During Tumour Growth and in Homograft Rejection
title_sort spleen weight in rats during tumour growth and in homograft rejection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008742/
https://www.ncbi.nlm.nih.gov/pubmed/4947347
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