Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone

Neonatal hamster kidney cells (BHK21/C13), challenged in monolayer culture for three days with crude rat liver histone, have been shown to exhibit increased malignant characteristics when injected subcutaneously into hamsters. In contrast to the controls, the challenged cells produced tumours which...

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Detalles Bibliográficos
Autores principales: Latner, A. L., Longstaff, E., Turner, G. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008778/
https://www.ncbi.nlm.nih.gov/pubmed/4694389
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author Latner, A. L.
Longstaff, E.
Turner, G. A.
author_facet Latner, A. L.
Longstaff, E.
Turner, G. A.
author_sort Latner, A. L.
collection PubMed
description Neonatal hamster kidney cells (BHK21/C13), challenged in monolayer culture for three days with crude rat liver histone, have been shown to exhibit increased malignant characteristics when injected subcutaneously into hamsters. In contrast to the controls, the challenged cells produced tumours which invaded either the epidermis or the body wall of their hosts and frequently caused extensive visceral metastases. In vitro studies of the cell cultures, during and after histone treatment, suggested that cellular “transformation” rather than selection was effected by the crude histone preparation. Cells from the primary tumours of both control and test groups appeared morphologically identical but after sub-culture in vitro they retained their respective growth characteristics on reinoculation. IMAGES:
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spelling pubmed-20087782009-09-10 Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone Latner, A. L. Longstaff, E. Turner, G. A. Br J Cancer Articles Neonatal hamster kidney cells (BHK21/C13), challenged in monolayer culture for three days with crude rat liver histone, have been shown to exhibit increased malignant characteristics when injected subcutaneously into hamsters. In contrast to the controls, the challenged cells produced tumours which invaded either the epidermis or the body wall of their hosts and frequently caused extensive visceral metastases. In vitro studies of the cell cultures, during and after histone treatment, suggested that cellular “transformation” rather than selection was effected by the crude histone preparation. Cells from the primary tumours of both control and test groups appeared morphologically identical but after sub-culture in vitro they retained their respective growth characteristics on reinoculation. IMAGES: Nature Publishing Group 1973-03 /pmc/articles/PMC2008778/ /pubmed/4694389 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Latner, A. L.
Longstaff, E.
Turner, G. A.
Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title_full Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title_fullStr Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title_full_unstemmed Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title_short Enhanced Malignant Behaviour of Cells Treated with Crude Rat Liver Histone
title_sort enhanced malignant behaviour of cells treated with crude rat liver histone
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008778/
https://www.ncbi.nlm.nih.gov/pubmed/4694389
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