Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens

The sequential histological changes and neoplastic response occurring in the subcutaneous tissue of rats after injection of surfactants or carcinogens were compared. Twice weekly subcutaneous injections of the surfactants Blue VRS and Light Green SF elicited a deranged connective tissue repair with...

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Autores principales: Hooson, J., Grasso, P., Gangolli, S. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008779/
https://www.ncbi.nlm.nih.gov/pubmed/4694390
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author Hooson, J.
Grasso, P.
Gangolli, S. D.
author_facet Hooson, J.
Grasso, P.
Gangolli, S. D.
author_sort Hooson, J.
collection PubMed
description The sequential histological changes and neoplastic response occurring in the subcutaneous tissue of rats after injection of surfactants or carcinogens were compared. Twice weekly subcutaneous injections of the surfactants Blue VRS and Light Green SF elicited a deranged connective tissue repair with continued proliferation of fibroblasts and extensive collagen desposition. In contrast, the carcinogens N-methyl-N-nitrosourea (MNU) and N-nitroquinoline-N-oxide (NQO) appeared to inhibit connective tissue repair and produce morphologically abnormal fibroblasts. The spectrum of neoplastic response was also found to differ. Surfactants gave rise to local sarcomata only after about 47 weeks, whereas carcinogens produced local sarcomata and adenocarcinomata after 20 and 12 weeks respectively. IMAGES:
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spelling pubmed-20087792009-09-10 Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens Hooson, J. Grasso, P. Gangolli, S. D. Br J Cancer Articles The sequential histological changes and neoplastic response occurring in the subcutaneous tissue of rats after injection of surfactants or carcinogens were compared. Twice weekly subcutaneous injections of the surfactants Blue VRS and Light Green SF elicited a deranged connective tissue repair with continued proliferation of fibroblasts and extensive collagen desposition. In contrast, the carcinogens N-methyl-N-nitrosourea (MNU) and N-nitroquinoline-N-oxide (NQO) appeared to inhibit connective tissue repair and produce morphologically abnormal fibroblasts. The spectrum of neoplastic response was also found to differ. Surfactants gave rise to local sarcomata only after about 47 weeks, whereas carcinogens produced local sarcomata and adenocarcinomata after 20 and 12 weeks respectively. IMAGES: Nature Publishing Group 1973-03 /pmc/articles/PMC2008779/ /pubmed/4694390 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Hooson, J.
Grasso, P.
Gangolli, S. D.
Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title_full Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title_fullStr Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title_full_unstemmed Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title_short Injection Site Tumours and Preceding Pathological Changes in rats Treated Subcutaneously with Surfactants and Carcinogens
title_sort injection site tumours and preceding pathological changes in rats treated subcutaneously with surfactants and carcinogens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008779/
https://www.ncbi.nlm.nih.gov/pubmed/4694390
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