The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association

The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results fro...

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Detalles Bibliográficos
Autores principales: Williams, D. J., Clark, R. P., Rabin, B. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008791/
https://www.ncbi.nlm.nih.gov/pubmed/4144962
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author Williams, D. J.
Clark, R. P.
Rabin, B. R.
author_facet Williams, D. J.
Clark, R. P.
Rabin, B. R.
author_sort Williams, D. J.
collection PubMed
description The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.
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spelling pubmed-20087912009-09-10 The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association Williams, D. J. Clark, R. P. Rabin, B. R. Br J Cancer Articles The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations. Nature Publishing Group 1973-04 /pmc/articles/PMC2008791/ /pubmed/4144962 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Williams, D. J.
Clark, R. P.
Rabin, B. R.
The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title_full The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title_fullStr The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title_full_unstemmed The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title_short The Effects of Aflatoxin B1 in vivo on Membrane—Ribosome Association
title_sort effects of aflatoxin b1 in vivo on membrane—ribosome association
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008791/
https://www.ncbi.nlm.nih.gov/pubmed/4144962
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