Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour

Specific substances binding [(3)H]-triamcinolone acetonide have been demonstrated in the cytoplasmic fraction of the R3230AC mammary carcinoma using sucrose gradient centrifugation. These receptors, which exhibit sedimentation coefficients of 8-9 Svedberg units, are relatively specific for glucocort...

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Detalles Bibliográficos
Autores principales: Gardner, D. G., Wittliff, J. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008813/
https://www.ncbi.nlm.nih.gov/pubmed/4352788
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author Gardner, D. G.
Wittliff, J. L.
author_facet Gardner, D. G.
Wittliff, J. L.
author_sort Gardner, D. G.
collection PubMed
description Specific substances binding [(3)H]-triamcinolone acetonide have been demonstrated in the cytoplasmic fraction of the R3230AC mammary carcinoma using sucrose gradient centrifugation. These receptors, which exhibit sedimentation coefficients of 8-9 Svedberg units, are relatively specific for glucocorticoid ligands and possess a high affinity for triamcinolone acetonide (K(d)∼7 × 10(-8) mol/1).
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spelling pubmed-20088132009-09-10 Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour Gardner, D. G. Wittliff, J. L. Br J Cancer Articles Specific substances binding [(3)H]-triamcinolone acetonide have been demonstrated in the cytoplasmic fraction of the R3230AC mammary carcinoma using sucrose gradient centrifugation. These receptors, which exhibit sedimentation coefficients of 8-9 Svedberg units, are relatively specific for glucocorticoid ligands and possess a high affinity for triamcinolone acetonide (K(d)∼7 × 10(-8) mol/1). Nature Publishing Group 1973-06 /pmc/articles/PMC2008813/ /pubmed/4352788 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Gardner, D. G.
Wittliff, J. L.
Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title_full Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title_fullStr Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title_full_unstemmed Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title_short Demonstration of a Glucocorticoid Hormone-receptor Complex in the Cytoplasm of a Hormone-Responsive Tumour
title_sort demonstration of a glucocorticoid hormone-receptor complex in the cytoplasm of a hormone-responsive tumour
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008813/
https://www.ncbi.nlm.nih.gov/pubmed/4352788
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AT wittliffjl demonstrationofaglucocorticoidhormonereceptorcomplexinthecytoplasmofahormoneresponsivetumour

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