Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro

Freshly excised human embryonic tissue used as antigen to test lymphocytes from a cancer bearing patient gives a “normal tissue” result of about 10% in the macrophage electrophoresis migration (MEM) test. When, however, it is grown in vitro and then used as an antigenic stimulant to cancer lymphocyt...

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Detalles Bibliográficos
Autores principales: Field, E. J., Hughes, D., Caspary, E. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008819/
https://www.ncbi.nlm.nih.gov/pubmed/4737227
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author Field, E. J.
Hughes, D.
Caspary, E. A.
author_facet Field, E. J.
Hughes, D.
Caspary, E. A.
author_sort Field, E. J.
collection PubMed
description Freshly excised human embryonic tissue used as antigen to test lymphocytes from a cancer bearing patient gives a “normal tissue” result of about 10% in the macrophage electrophoresis migration (MEM) test. When, however, it is grown in vitro and then used as an antigenic stimulant to cancer lymphocytes, a “cancerlike” result (about 15%) is produced. These new antigenic determinant(s) akin to those associated with cancer basic protein appear rapidly (within 5.5 hours) in vitro. Cultures of “normal” cells are thus antigenically different from the same cells in context in vivo.
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spelling pubmed-20088192009-09-10 Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro Field, E. J. Hughes, D. Caspary, E. A. Br J Cancer Articles Freshly excised human embryonic tissue used as antigen to test lymphocytes from a cancer bearing patient gives a “normal tissue” result of about 10% in the macrophage electrophoresis migration (MEM) test. When, however, it is grown in vitro and then used as an antigenic stimulant to cancer lymphocytes, a “cancerlike” result (about 15%) is produced. These new antigenic determinant(s) akin to those associated with cancer basic protein appear rapidly (within 5.5 hours) in vitro. Cultures of “normal” cells are thus antigenically different from the same cells in context in vivo. Nature Publishing Group 1973-06 /pmc/articles/PMC2008819/ /pubmed/4737227 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Field, E. J.
Hughes, D.
Caspary, E. A.
Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title_full Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title_fullStr Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title_full_unstemmed Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title_short Rapid Development of a Cancer-like Antigen in Normal Tissue in vitro
title_sort rapid development of a cancer-like antigen in normal tissue in vitro
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008819/
https://www.ncbi.nlm.nih.gov/pubmed/4737227
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