Isolation of Arginine Acceptor-Proteins from Normal Rat Liver and Novikoff Hepatoma Supernatant*

In the present report a procedure for the isolation of more specific arginine receptors from the soluble fraction of rat liver and Novikoff hepatoma is described. In normal rat liver the specific activity of these receptors from the soluble fraction of rat liver and Novikoff hepatoma is described. In normal rat liver the specific activity of these receptors is fifteen times greater than that of the other proteins whereas in the Novikoff it is only three to four times higher. Attempts to sub-fractionate this class of acceptors would seem to indicate a relative homogeneity.