Immunological Control of Polyoma Virus Oncogenesis in Mice

Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized w...

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Autores principales: Gaugas, J. M., Allison, A. C., Chesterman, F. C., Rees, R. J. W., Hirsch, M. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008828/
https://www.ncbi.nlm.nih.gov/pubmed/4346752
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author Gaugas, J. M.
Allison, A. C.
Chesterman, F. C.
Rees, R. J. W.
Hirsch, M. S.
author_facet Gaugas, J. M.
Allison, A. C.
Chesterman, F. C.
Rees, R. J. W.
Hirsch, M. S.
author_sort Gaugas, J. M.
collection PubMed
description Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions. IMAGES:
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spelling pubmed-20088282009-09-10 Immunological Control of Polyoma Virus Oncogenesis in Mice Gaugas, J. M. Allison, A. C. Chesterman, F. C. Rees, R. J. W. Hirsch, M. S. Br J Cancer Articles Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions. IMAGES: Nature Publishing Group 1973-01 /pmc/articles/PMC2008828/ /pubmed/4346752 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Gaugas, J. M.
Allison, A. C.
Chesterman, F. C.
Rees, R. J. W.
Hirsch, M. S.
Immunological Control of Polyoma Virus Oncogenesis in Mice
title Immunological Control of Polyoma Virus Oncogenesis in Mice
title_full Immunological Control of Polyoma Virus Oncogenesis in Mice
title_fullStr Immunological Control of Polyoma Virus Oncogenesis in Mice
title_full_unstemmed Immunological Control of Polyoma Virus Oncogenesis in Mice
title_short Immunological Control of Polyoma Virus Oncogenesis in Mice
title_sort immunological control of polyoma virus oncogenesis in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008828/
https://www.ncbi.nlm.nih.gov/pubmed/4346752
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