Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats

A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a...

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Autores principales: Jabara, Anne G., Toyne, P. H., Harcourt, Alison G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008829/
https://www.ncbi.nlm.nih.gov/pubmed/4686179
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author Jabara, Anne G.
Toyne, P. H.
Harcourt, Alison G.
author_facet Jabara, Anne G.
Toyne, P. H.
Harcourt, Alison G.
author_sort Jabara, Anne G.
collection PubMed
description A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone. In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens.
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spelling pubmed-20088292009-09-10 Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats Jabara, Anne G. Toyne, P. H. Harcourt, Alison G. Br J Cancer Articles A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone. In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens. Nature Publishing Group 1973-01 /pmc/articles/PMC2008829/ /pubmed/4686179 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Jabara, Anne G.
Toyne, P. H.
Harcourt, Alison G.
Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title_full Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title_fullStr Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title_full_unstemmed Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title_short Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
title_sort effects of time and duration of progesterone administration on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in sprague-dawley rats
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008829/
https://www.ncbi.nlm.nih.gov/pubmed/4686179
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