A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host

An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tiss...

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Detalles Bibliográficos
Autores principales: Thomson, D. M. P., Alexander, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008836/
https://www.ncbi.nlm.nih.gov/pubmed/4631228
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author Thomson, D. M. P.
Alexander, P.
author_facet Thomson, D. M. P.
Alexander, P.
author_sort Thomson, D. M. P.
collection PubMed
description An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tissue and has the properties to be expected from the well established tumour-specific transplantation-type antigen while the other, referred to as OEA I, was present in all rat sarcomata tested as well as in early embryos. Two other embryonic components were detected in the sarcoma but these were not immunogenic in the rat. The properties of these tumour-associated “antigens” in the membrane of rat sarcomata are summarized below: [Table: see text] IMAGES:
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spelling pubmed-20088362009-09-10 A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host Thomson, D. M. P. Alexander, P. Br J Cancer Articles An analysis of the constituents of the plasma membrane of a methylcholanthrene-induced sarcoma (the MC1 tumour) in a hooded rat revealed four tumour-associated macromolecules. Two of these were antigenic in the syngeneic host, one was unique to the MC1 tumour and could not be detected in embryo tissue and has the properties to be expected from the well established tumour-specific transplantation-type antigen while the other, referred to as OEA I, was present in all rat sarcomata tested as well as in early embryos. Two other embryonic components were detected in the sarcoma but these were not immunogenic in the rat. The properties of these tumour-associated “antigens” in the membrane of rat sarcomata are summarized below: [Table: see text] IMAGES: Nature Publishing Group 1973-01 /pmc/articles/PMC2008836/ /pubmed/4631228 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Thomson, D. M. P.
Alexander, P.
A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title_full A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title_fullStr A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title_full_unstemmed A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title_short A Cross-Reacting Embryonic Antigen in the Membrane of Rat Sarcoma Cells which is Immunogenic in the Syngeneic Host
title_sort cross-reacting embryonic antigen in the membrane of rat sarcoma cells which is immunogenic in the syngeneic host
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008836/
https://www.ncbi.nlm.nih.gov/pubmed/4631228
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AT thomsondmp crossreactingembryonicantigeninthemembraneofratsarcomacellswhichisimmunogenicinthesyngeneichost
AT alexanderp crossreactingembryonicantigeninthemembraneofratsarcomacellswhichisimmunogenicinthesyngeneichost

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