A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue

(1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method. (2) Basic protein prepared from human tumour tissue has antigenic properties which differ fro...

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Detalles Bibliográficos
Autores principales: Dickinson, J. P., Caspary, E. A., Field, E. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008838/
https://www.ncbi.nlm.nih.gov/pubmed/4735112
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author Dickinson, J. P.
Caspary, E. A.
Field, E. J.
author_facet Dickinson, J. P.
Caspary, E. A.
Field, E. J.
author_sort Dickinson, J. P.
collection PubMed
description (1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method. (2) Basic protein prepared from human tumour tissue has antigenic properties which differ from basic protein prepared from normal tissues, from hyperplastic tissue and even tumour bearing host tissue. (3) Tumour type antigenic molecules are at least 10(4) times less numerous on normal cells than on tumour cells. If our reasoning is accepted then they are absent from normal cells, and thus restricted in vivo to malignant cells. (4) Hyperplastic tissues (gynaecomastia, etc.) do not contain cancer basic protein. (5) Human chronic lymphatic leukaemic leucocytes possess the same type of cancer antigenic activity as solid tumours. This antigenic activity is not shared by normal lymphocytes.
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spelling pubmed-20088382009-09-10 A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue Dickinson, J. P. Caspary, E. A. Field, E. J. Br J Cancer Articles (1) The antigenic activity of basic protein extracts of a variety of human tissues towards sensitized lymphocytes from cancer patients has been studied using the macrophage electrophoretic migration method. (2) Basic protein prepared from human tumour tissue has antigenic properties which differ from basic protein prepared from normal tissues, from hyperplastic tissue and even tumour bearing host tissue. (3) Tumour type antigenic molecules are at least 10(4) times less numerous on normal cells than on tumour cells. If our reasoning is accepted then they are absent from normal cells, and thus restricted in vivo to malignant cells. (4) Hyperplastic tissues (gynaecomastia, etc.) do not contain cancer basic protein. (5) Human chronic lymphatic leukaemic leucocytes possess the same type of cancer antigenic activity as solid tumours. This antigenic activity is not shared by normal lymphocytes. Nature Publishing Group 1973-02 /pmc/articles/PMC2008838/ /pubmed/4735112 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Dickinson, J. P.
Caspary, E. A.
Field, E. J.
A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title_full A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title_fullStr A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title_full_unstemmed A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title_short A Common Tumour Specific Antigen: I. Restriction in vivo to Malignant Neoplastic Tissue
title_sort common tumour specific antigen: i. restriction in vivo to malignant neoplastic tissue
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008838/
https://www.ncbi.nlm.nih.gov/pubmed/4735112
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