Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma

The radiosensitizing effect of iodoacetamide was studied in a C3H mouse mammary carcinoma together with its toxicity to the host. TCD(50) or radiation dose to yield 50% tumour control frequency was determined in tumours treated or untreated with the agent. Results indicated that 15 mg/kg of iodoacet...

Descripción completa

Detalles Bibliográficos
Autores principales: Urano, M., Tanaka, N., Hayashi, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008891/
https://www.ncbi.nlm.nih.gov/pubmed/4730179
_version_ 1782136006326091776
author Urano, M.
Tanaka, N.
Hayashi, S.
author_facet Urano, M.
Tanaka, N.
Hayashi, S.
author_sort Urano, M.
collection PubMed
description The radiosensitizing effect of iodoacetamide was studied in a C3H mouse mammary carcinoma together with its toxicity to the host. TCD(50) or radiation dose to yield 50% tumour control frequency was determined in tumours treated or untreated with the agent. Results indicated that 15 mg/kg of iodoacetamide sensitized hypoxic tumour cells, as did atmospheric oxygen, and the sensitization was not detectable below this dose. Experiments with fractionated treatments suggested that the reoxygenation occurring during the treatment intervals of 24 hours might be more important in the sterilization of tumour cells than the agent.
format Text
id pubmed-2008891
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20088912009-09-10 Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma Urano, M. Tanaka, N. Hayashi, S. Br J Cancer Short Communication The radiosensitizing effect of iodoacetamide was studied in a C3H mouse mammary carcinoma together with its toxicity to the host. TCD(50) or radiation dose to yield 50% tumour control frequency was determined in tumours treated or untreated with the agent. Results indicated that 15 mg/kg of iodoacetamide sensitized hypoxic tumour cells, as did atmospheric oxygen, and the sensitization was not detectable below this dose. Experiments with fractionated treatments suggested that the reoxygenation occurring during the treatment intervals of 24 hours might be more important in the sterilization of tumour cells than the agent. Nature Publishing Group 1973-08 /pmc/articles/PMC2008891/ /pubmed/4730179 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Urano, M.
Tanaka, N.
Hayashi, S.
Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title_full Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title_fullStr Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title_full_unstemmed Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title_short Sensitizing Ability and Toxicity of Iodoacetamide in Radiotherapy of a C3H Mouse Mammary Carcinoma
title_sort sensitizing ability and toxicity of iodoacetamide in radiotherapy of a c3h mouse mammary carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008891/
https://www.ncbi.nlm.nih.gov/pubmed/4730179
work_keys_str_mv AT uranom sensitizingabilityandtoxicityofiodoacetamideinradiotherapyofac3hmousemammarycarcinoma
AT tanakan sensitizingabilityandtoxicityofiodoacetamideinradiotherapyofac3hmousemammarycarcinoma
AT hayashis sensitizingabilityandtoxicityofiodoacetamideinradiotherapyofac3hmousemammarycarcinoma

Ejemplares similares