Immunotherapy of the Dunning Leukaemia with Thymic Extracts

Injections of thymic extract (TE), TE primed lymphocytes or normal lymph node cells were effective in bringing about total remission of the Dunning leukaemia in inbred Fisher CD rats. Survival greater than 365 days occurred in 10-80% of the various treated groups whereas untreated leukaemic rats, or...

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Detalles Bibliográficos
Autores principales: Khaw, Ban An, Rule, A. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008900/
https://www.ncbi.nlm.nih.gov/pubmed/4759937
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author Khaw, Ban An
Rule, A. H.
author_facet Khaw, Ban An
Rule, A. H.
author_sort Khaw, Ban An
collection PubMed
description Injections of thymic extract (TE), TE primed lymphocytes or normal lymph node cells were effective in bringing about total remission of the Dunning leukaemia in inbred Fisher CD rats. Survival greater than 365 days occurred in 10-80% of the various treated groups whereas untreated leukaemic rats, or leukaemic rats treated with spleen “mock thymus extract” or bovine serum albumin, died within an average of 10-17 days. Administration of antilymphocyte serum into leukaemic rats enhanced their death rate. Stimulation of cell mediated immunity via the production of functional thymus stimulated lymphocytes is postulated as the mechanism by which tumour rejection occurred.
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spelling pubmed-20089002009-09-10 Immunotherapy of the Dunning Leukaemia with Thymic Extracts Khaw, Ban An Rule, A. H. Br J Cancer Articles Injections of thymic extract (TE), TE primed lymphocytes or normal lymph node cells were effective in bringing about total remission of the Dunning leukaemia in inbred Fisher CD rats. Survival greater than 365 days occurred in 10-80% of the various treated groups whereas untreated leukaemic rats, or leukaemic rats treated with spleen “mock thymus extract” or bovine serum albumin, died within an average of 10-17 days. Administration of antilymphocyte serum into leukaemic rats enhanced their death rate. Stimulation of cell mediated immunity via the production of functional thymus stimulated lymphocytes is postulated as the mechanism by which tumour rejection occurred. Nature Publishing Group 1973-10 /pmc/articles/PMC2008900/ /pubmed/4759937 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Khaw, Ban An
Rule, A. H.
Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title_full Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title_fullStr Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title_full_unstemmed Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title_short Immunotherapy of the Dunning Leukaemia with Thymic Extracts
title_sort immunotherapy of the dunning leukaemia with thymic extracts
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008900/
https://www.ncbi.nlm.nih.gov/pubmed/4759937
work_keys_str_mv AT khawbanan immunotherapyofthedunningleukaemiawiththymicextracts
AT ruleah immunotherapyofthedunningleukaemiawiththymicextracts

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