Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma

The records of 194 patients with thyroid carcinoma treated with (131)I, representing all cases thus treated in Denmark from 1948 to 1972, were reviewed. Two cases of myeloid leukaemia were found compared with 0·097 expected cases of non-lymphocytic leukaemia (0·05 > P > 0·01). In 5 series of (...

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Autores principales: Brincker, H., Hansen, H. S., Andersen, A. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008977/
https://www.ncbi.nlm.nih.gov/pubmed/4517840
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author Brincker, H.
Hansen, H. S.
Andersen, A. P.
author_facet Brincker, H.
Hansen, H. S.
Andersen, A. P.
author_sort Brincker, H.
collection PubMed
description The records of 194 patients with thyroid carcinoma treated with (131)I, representing all cases thus treated in Denmark from 1948 to 1972, were reviewed. Two cases of myeloid leukaemia were found compared with 0·097 expected cases of non-lymphocytic leukaemia (0·05 > P > 0·01). In 5 series of (131)I treated thyroid carcinomata, 10 cases of myeloid leukaemia occurred in a total of 487 patients, corresponding to a frequency of leukaemia of about 2%. These findings appear to show that (131)I treatment of thyroid carcinoma is associated with a certain risk of development of leukaemia. This risk must be considered when treatment of localized thyroid carcinoma is planned.
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spelling pubmed-20089772009-09-10 Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma Brincker, H. Hansen, H. S. Andersen, A. P. Br J Cancer Articles The records of 194 patients with thyroid carcinoma treated with (131)I, representing all cases thus treated in Denmark from 1948 to 1972, were reviewed. Two cases of myeloid leukaemia were found compared with 0·097 expected cases of non-lymphocytic leukaemia (0·05 > P > 0·01). In 5 series of (131)I treated thyroid carcinomata, 10 cases of myeloid leukaemia occurred in a total of 487 patients, corresponding to a frequency of leukaemia of about 2%. These findings appear to show that (131)I treatment of thyroid carcinoma is associated with a certain risk of development of leukaemia. This risk must be considered when treatment of localized thyroid carcinoma is planned. Nature Publishing Group 1973-09 /pmc/articles/PMC2008977/ /pubmed/4517840 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Brincker, H.
Hansen, H. S.
Andersen, A. P.
Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title_full Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title_fullStr Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title_full_unstemmed Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title_short Induction of Leukaemia by (131)I Treatment of Thyroid Carcinoma
title_sort induction of leukaemia by (131)i treatment of thyroid carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008977/
https://www.ncbi.nlm.nih.gov/pubmed/4517840
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