Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host

Mouse myeloma cells (MPC-11) secreting gamma-2-b globulin were shown to proliferate into solid tumours after transplantation into the hamster cheek pouch. The implanted tumours continued to grow during the first 2 weeks; thereafter they diminished in size and disappeared completely a month after tra...

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Detalles Bibliográficos
Autores principales: Benbassat, J., Slavin, M., Zlotnick, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008992/
https://www.ncbi.nlm.nih.gov/pubmed/4133782
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author Benbassat, J.
Slavin, M.
Zlotnick, A.
author_facet Benbassat, J.
Slavin, M.
Zlotnick, A.
author_sort Benbassat, J.
collection PubMed
description Mouse myeloma cells (MPC-11) secreting gamma-2-b globulin were shown to proliferate into solid tumours after transplantation into the hamster cheek pouch. The implanted tumours continued to grow during the first 2 weeks; thereafter they diminished in size and disappeared completely a month after transplantation. The specific MPC-11 gammaglobulin could be detected in the serum of the hosts within 2 days after the transplantation and the changes in its concentration roughly correlated with the tumour size. The estimated half-life of the MPC-11 gammaglobulin in the circulation of the tumour-bearing hamsters was 4-6 days. Host resistance was demonstrated in tumour-bearing hamsters by their failure to develop tumours on second challenge with MPC-11 cells. IMAGES:
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spelling pubmed-20089922009-09-10 Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host Benbassat, J. Slavin, M. Zlotnick, A. Br J Cancer Articles Mouse myeloma cells (MPC-11) secreting gamma-2-b globulin were shown to proliferate into solid tumours after transplantation into the hamster cheek pouch. The implanted tumours continued to grow during the first 2 weeks; thereafter they diminished in size and disappeared completely a month after transplantation. The specific MPC-11 gammaglobulin could be detected in the serum of the hosts within 2 days after the transplantation and the changes in its concentration roughly correlated with the tumour size. The estimated half-life of the MPC-11 gammaglobulin in the circulation of the tumour-bearing hamsters was 4-6 days. Host resistance was demonstrated in tumour-bearing hamsters by their failure to develop tumours on second challenge with MPC-11 cells. IMAGES: Nature Publishing Group 1974-02 /pmc/articles/PMC2008992/ /pubmed/4133782 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Benbassat, J.
Slavin, M.
Zlotnick, A.
Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title_full Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title_fullStr Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title_full_unstemmed Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title_short Transplantation of Mouse Plasmacytoma to the Hamster's Cheek Pouch: I. Changes in Tumour Size and Paraprotein Concentration in the Serum of the Host
title_sort transplantation of mouse plasmacytoma to the hamster's cheek pouch: i. changes in tumour size and paraprotein concentration in the serum of the host
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008992/
https://www.ncbi.nlm.nih.gov/pubmed/4133782
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AT zlotnicka transplantationofmouseplasmacytomatothehamsterscheekpouchichangesintumoursizeandparaproteinconcentrationintheserumofthehost

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