A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease

Doxorubicin in a dose of 60 mg/m(2) has been used in the treatment of 23 patients with advanced malignant disease, 18 of whom had carcinoma of the breast. The drug has significant clinical activity on its own, prolonged dosage may be required to obtain a response, and there is a risk of cerebral met...

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Detalles Bibliográficos
Autores principales: Cole, M. P., Todd, I. D. H., Wilkinson, P. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008997/
https://www.ncbi.nlm.nih.gov/pubmed/4598084
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author Cole, M. P.
Todd, I. D. H.
Wilkinson, P. M.
author_facet Cole, M. P.
Todd, I. D. H.
Wilkinson, P. M.
author_sort Cole, M. P.
collection PubMed
description Doxorubicin in a dose of 60 mg/m(2) has been used in the treatment of 23 patients with advanced malignant disease, 18 of whom had carcinoma of the breast. The drug has significant clinical activity on its own, prolonged dosage may be required to obtain a response, and there is a risk of cerebral metastases becoming manifest during treatment which is otherwise successful. Cardiac toxicity appears to be acceptably low with this dose regimen.
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spelling pubmed-20089972009-09-10 A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease Cole, M. P. Todd, I. D. H. Wilkinson, P. M. Br J Cancer Articles Doxorubicin in a dose of 60 mg/m(2) has been used in the treatment of 23 patients with advanced malignant disease, 18 of whom had carcinoma of the breast. The drug has significant clinical activity on its own, prolonged dosage may be required to obtain a response, and there is a risk of cerebral metastases becoming manifest during treatment which is otherwise successful. Cardiac toxicity appears to be acceptably low with this dose regimen. Nature Publishing Group 1974-02 /pmc/articles/PMC2008997/ /pubmed/4598084 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Cole, M. P.
Todd, I. D. H.
Wilkinson, P. M.
A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title_full A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title_fullStr A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title_full_unstemmed A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title_short A Preliminary Trial of Doxorubicin in Advanced Breast Cancer and Other Malignant Disease
title_sort preliminary trial of doxorubicin in advanced breast cancer and other malignant disease
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2008997/
https://www.ncbi.nlm.nih.gov/pubmed/4598084
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