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Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*

Oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) to hamsters at a concentration of 50-83 μg/ml in the drinking water resulted in a high incidence of tumours in the glandular stomach. Short-term administration of MNNG for 4-6 months resulted in more adenocarcinomata in the glandular...

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Autores principales: Kogure, K., Sasadaira, H., Kawachi, T., Shimosato, Y., Tokunaga, A., Fujimura, S., Sugimura, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009001/
https://www.ncbi.nlm.nih.gov/pubmed/4830138
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author Kogure, K.
Sasadaira, H.
Kawachi, T.
Shimosato, Y.
Tokunaga, A.
Fujimura, S.
Sugimura, T.
author_facet Kogure, K.
Sasadaira, H.
Kawachi, T.
Shimosato, Y.
Tokunaga, A.
Fujimura, S.
Sugimura, T.
author_sort Kogure, K.
collection PubMed
description Oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) to hamsters at a concentration of 50-83 μg/ml in the drinking water resulted in a high incidence of tumours in the glandular stomach. Short-term administration of MNNG for 4-6 months resulted in more adenocarcinomata in the glandular stomach than long-term administration for 7-8 months. One case of metastasis of an adenocarcinoma of the glandular stomach to the liver and 2 cases of metastasis to the regional lymph nodes were found. Spindle cell sarcomata in the glandular stomach and adenocarcinomata in the duodenum were also often produced. Oral administration of MNNG at the very high concentration of 500-2000 μg/ml induced a hepatic cell carcinoma, intrahepatic bile duct carcinomata, bile duct cystadenomata and cystic dilatation, and a haemangioma in the liver but no tumour in the glandular stomach. Sequential morphological studies on the glandular stomach of hamsters receiving 50 μg/ml of MNNG in the drinking water showed 3 stages of change of the mucosa. The mucosa became atrophic and eroded in the first 16 weeks. Irregular atypical glands developed at the margins of erosions and proliferation of spindle cells in the submucosa were found after 18 weeks. Spindle cell sarcomata developed in animals after 20 weeks. Adenocarcinomata developed between 25 and 32 weeks. IMAGES:
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spelling pubmed-20090012009-09-10 Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine* Kogure, K. Sasadaira, H. Kawachi, T. Shimosato, Y. Tokunaga, A. Fujimura, S. Sugimura, T. Br J Cancer Articles Oral administration of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) to hamsters at a concentration of 50-83 μg/ml in the drinking water resulted in a high incidence of tumours in the glandular stomach. Short-term administration of MNNG for 4-6 months resulted in more adenocarcinomata in the glandular stomach than long-term administration for 7-8 months. One case of metastasis of an adenocarcinoma of the glandular stomach to the liver and 2 cases of metastasis to the regional lymph nodes were found. Spindle cell sarcomata in the glandular stomach and adenocarcinomata in the duodenum were also often produced. Oral administration of MNNG at the very high concentration of 500-2000 μg/ml induced a hepatic cell carcinoma, intrahepatic bile duct carcinomata, bile duct cystadenomata and cystic dilatation, and a haemangioma in the liver but no tumour in the glandular stomach. Sequential morphological studies on the glandular stomach of hamsters receiving 50 μg/ml of MNNG in the drinking water showed 3 stages of change of the mucosa. The mucosa became atrophic and eroded in the first 16 weeks. Irregular atypical glands developed at the margins of erosions and proliferation of spindle cells in the submucosa were found after 18 weeks. Spindle cell sarcomata developed in animals after 20 weeks. Adenocarcinomata developed between 25 and 32 weeks. IMAGES: Nature Publishing Group 1974-02 /pmc/articles/PMC2009001/ /pubmed/4830138 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Kogure, K.
Sasadaira, H.
Kawachi, T.
Shimosato, Y.
Tokunaga, A.
Fujimura, S.
Sugimura, T.
Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title_full Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title_fullStr Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title_full_unstemmed Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title_short Further Studies on Induction of Stomach Cancer in Hamsters by N-methyl-N′-nitro-N-nitrosoguanidine*
title_sort further studies on induction of stomach cancer in hamsters by n-methyl-n′-nitro-n-nitrosoguanidine*
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009001/
https://www.ncbi.nlm.nih.gov/pubmed/4830138
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