Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture

Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture. This work examines these results in greater detail. The kinetics of the uptake process into HEp/2 cells and its p...

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Autores principales: Morley, T. G, Dendy, P. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1973
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009046/
https://www.ncbi.nlm.nih.gov/pubmed/4198975
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author Morley, T. G
Dendy, P. P.
author_facet Morley, T. G
Dendy, P. P.
author_sort Morley, T. G
collection PubMed
description Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture. This work examines these results in greater detail. The kinetics of the uptake process into HEp/2 cells and its precise dependence on the experimental conditions are described. It is shown that an alkaline phosphatase (APase) is present on the surface of HEp/2 cells and that this is responsible for the uptake of label. L cells do not take up the radioactive label and are shown not to possess significant quantities of APase. IMAGES:
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spelling pubmed-20090462009-09-10 Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture Morley, T. G Dendy, P. P. Br J Cancer Articles Earlier papers have described the selective uptake of the radioactive drug 2-methyl 6,7-ditritio-1, 4-naphthoquinol bis disodium phosphate into some human tumour cells in tissue culture. This work examines these results in greater detail. The kinetics of the uptake process into HEp/2 cells and its precise dependence on the experimental conditions are described. It is shown that an alkaline phosphatase (APase) is present on the surface of HEp/2 cells and that this is responsible for the uptake of label. L cells do not take up the radioactive label and are shown not to possess significant quantities of APase. IMAGES: Nature Publishing Group 1973-07 /pmc/articles/PMC2009046/ /pubmed/4198975 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Morley, T. G
Dendy, P. P.
Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title_full Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title_fullStr Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title_full_unstemmed Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title_short Mechanisms of Selective Uptake of 2-Methyl-1, 4-Naphthoquinol Bis Disodium Phosphate, into some Mammalian Cells in Tissue Culture
title_sort mechanisms of selective uptake of 2-methyl-1, 4-naphthoquinol bis disodium phosphate, into some mammalian cells in tissue culture
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009046/
https://www.ncbi.nlm.nih.gov/pubmed/4198975
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