Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*

Wistar rats were treated with a single dose of 30 mg/kg of DMN or with single doses of 100, 200 or 300 mg/kg of EMS. Tumours of the kidney developed in a few animals receiving EMS and in 33% of the male and 63% of the female rats treated with DMN alone. In the animals receiving DMN and, 8 hours late...

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Detalles Bibliográficos
Autores principales: Montesano, R., Mohr, U., Magee, P. N., Hilfrich, J., Haas, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009131/
https://www.ncbi.nlm.nih.gov/pubmed/4362449
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author Montesano, R.
Mohr, U.
Magee, P. N.
Hilfrich, J.
Haas, H.
author_facet Montesano, R.
Mohr, U.
Magee, P. N.
Hilfrich, J.
Haas, H.
author_sort Montesano, R.
collection PubMed
description Wistar rats were treated with a single dose of 30 mg/kg of DMN or with single doses of 100, 200 or 300 mg/kg of EMS. Tumours of the kidney developed in a few animals receiving EMS and in 33% of the male and 63% of the female rats treated with DMN alone. In the animals receiving DMN and, 8 hours later, a single dose of 100, 200 or 300 mg/kg of EMS, an additive effect was observed in the induction of kidney tumours. This additive effect was more pronounced in female than in male rats. Morphologically, the tumours were of epithelial and mesenchymal type with a preponderance of the former type. The significance of alkylation of the nucleic acids of the kidney observed with these two compounds is discussed in relation to the present findings. IMAGES:
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spelling pubmed-20091312009-09-10 Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate* Montesano, R. Mohr, U. Magee, P. N. Hilfrich, J. Haas, H. Br J Cancer Articles Wistar rats were treated with a single dose of 30 mg/kg of DMN or with single doses of 100, 200 or 300 mg/kg of EMS. Tumours of the kidney developed in a few animals receiving EMS and in 33% of the male and 63% of the female rats treated with DMN alone. In the animals receiving DMN and, 8 hours later, a single dose of 100, 200 or 300 mg/kg of EMS, an additive effect was observed in the induction of kidney tumours. This additive effect was more pronounced in female than in male rats. Morphologically, the tumours were of epithelial and mesenchymal type with a preponderance of the former type. The significance of alkylation of the nucleic acids of the kidney observed with these two compounds is discussed in relation to the present findings. IMAGES: Nature Publishing Group 1974-01 /pmc/articles/PMC2009131/ /pubmed/4362449 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Montesano, R.
Mohr, U.
Magee, P. N.
Hilfrich, J.
Haas, H.
Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title_full Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title_fullStr Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title_full_unstemmed Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title_short Additive Effect in the Induction of Kidney Tumours in Rats Treated with Dimethylnitrosamine and Ethylmethanesulphonate*
title_sort additive effect in the induction of kidney tumours in rats treated with dimethylnitrosamine and ethylmethanesulphonate*
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009131/
https://www.ncbi.nlm.nih.gov/pubmed/4362449
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