The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons

The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray...

Descripción completa

Detalles Bibliográficos
Autor principal: Denekamp, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009173/
https://www.ncbi.nlm.nih.gov/pubmed/4855057
_version_ 1782136062444830720
author Denekamp, J.
author_facet Denekamp, J.
author_sort Denekamp, J.
collection PubMed
description The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray treatment, in contrast with rapidly shrinking carcinomata. Neutrons were approximately three times more effective than x-rays, both for single doses and for two fractions given in 48 hours, when regrowth was used as a measure of response. This observation is closely similar to results previously obtained on a rat fibrosarcoma and contrasts with previous results from a mouse mammary carcinoma, and is in agreement with the hypothesis.
format Text
id pubmed-2009173
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20091732009-09-10 The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons Denekamp, J. Br J Cancer Articles The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray treatment, in contrast with rapidly shrinking carcinomata. Neutrons were approximately three times more effective than x-rays, both for single doses and for two fractions given in 48 hours, when regrowth was used as a measure of response. This observation is closely similar to results previously obtained on a rat fibrosarcoma and contrasts with previous results from a mouse mammary carcinoma, and is in agreement with the hypothesis. Nature Publishing Group 1974-04 /pmc/articles/PMC2009173/ /pubmed/4855057 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Denekamp, J.
The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title_full The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title_fullStr The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title_full_unstemmed The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title_short The Response of a Mouse Sarcoma to Single and Divided Doses of X-rays and Fast Neutrons
title_sort response of a mouse sarcoma to single and divided doses of x-rays and fast neutrons
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009173/
https://www.ncbi.nlm.nih.gov/pubmed/4855057
work_keys_str_mv AT denekampj theresponseofamousesarcomatosingleanddivideddosesofxraysandfastneutrons
AT denekampj responseofamousesarcomatosingleanddivideddosesofxraysandfastneutrons

Ejemplares similares