Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes

The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in thes...

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Detalles Bibliográficos
Autores principales: Levo, Y., Carnaud, C., Cohen, I. R., Trainin, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009180/
https://www.ncbi.nlm.nih.gov/pubmed/4152913
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author Levo, Y.
Carnaud, C.
Cohen, I. R.
Trainin, N.
author_facet Levo, Y.
Carnaud, C.
Cohen, I. R.
Trainin, N.
author_sort Levo, Y.
collection PubMed
description The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours.
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spelling pubmed-20091802009-09-10 Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes Levo, Y. Carnaud, C. Cohen, I. R. Trainin, N. Br J Cancer Articles The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours. Nature Publishing Group 1974-04 /pmc/articles/PMC2009180/ /pubmed/4152913 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Levo, Y.
Carnaud, C.
Cohen, I. R.
Trainin, N.
Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title_full Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title_fullStr Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title_full_unstemmed Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title_short Increased Incidence of Urethane Induced Lung Adenomata by Autosensitized Lymphocytes
title_sort increased incidence of urethane induced lung adenomata by autosensitized lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009180/
https://www.ncbi.nlm.nih.gov/pubmed/4152913
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AT carnaudc increasedincidenceofurethaneinducedlungadenomatabyautosensitizedlymphocytes
AT cohenir increasedincidenceofurethaneinducedlungadenomatabyautosensitizedlymphocytes
AT traininn increasedincidenceofurethaneinducedlungadenomatabyautosensitizedlymphocytes

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