Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa

The degree of migration inhibition in response to tissue extracts has been examined in leucocyte preparations obtained from patients with large intestinal cancer and from age and sex matched control individuals. A greater degree of migration inhibition was observed in response to a colorectal tumour...

Descripción completa

Detalles Bibliográficos
Autores principales: McIllmurray, M. B., Price, M. R., Langman, M. J. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009185/
https://www.ncbi.nlm.nih.gov/pubmed/4852478
_version_ 1782136064316538880
author McIllmurray, M. B.
Price, M. R.
Langman, M. J. S.
author_facet McIllmurray, M. B.
Price, M. R.
Langman, M. J. S.
author_sort McIllmurray, M. B.
collection PubMed
description The degree of migration inhibition in response to tissue extracts has been examined in leucocyte preparations obtained from patients with large intestinal cancer and from age and sex matched control individuals. A greater degree of migration inhibition was observed in response to a colorectal tumour extract in cells obtained from the cancer patients. Inhibition also tended to be more marked in response to the tumour extract than in response to a normal colonic mucosal extract in these patients. These results suggest that altered cellular immune reactivity is demonstrable by this simple in vitro technique in patients with large intestinal cancer.
format Text
id pubmed-2009185
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20091852009-09-10 Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa McIllmurray, M. B. Price, M. R. Langman, M. J. S. Br J Cancer Articles The degree of migration inhibition in response to tissue extracts has been examined in leucocyte preparations obtained from patients with large intestinal cancer and from age and sex matched control individuals. A greater degree of migration inhibition was observed in response to a colorectal tumour extract in cells obtained from the cancer patients. Inhibition also tended to be more marked in response to the tumour extract than in response to a normal colonic mucosal extract in these patients. These results suggest that altered cellular immune reactivity is demonstrable by this simple in vitro technique in patients with large intestinal cancer. Nature Publishing Group 1974-04 /pmc/articles/PMC2009185/ /pubmed/4852478 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
McIllmurray, M. B.
Price, M. R.
Langman, M. J. S.
Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title_full Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title_fullStr Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title_full_unstemmed Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title_short Inhibition of Leucocyte Migration in Patients with Large Intestinal Cancer by Extracts Prepared from Large Intestinal Tumours and from Normal Colonic Mucosa
title_sort inhibition of leucocyte migration in patients with large intestinal cancer by extracts prepared from large intestinal tumours and from normal colonic mucosa
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009185/
https://www.ncbi.nlm.nih.gov/pubmed/4852478
work_keys_str_mv AT mcillmurraymb inhibitionofleucocytemigrationinpatientswithlargeintestinalcancerbyextractspreparedfromlargeintestinaltumoursandfromnormalcolonicmucosa
AT pricemr inhibitionofleucocytemigrationinpatientswithlargeintestinalcancerbyextractspreparedfromlargeintestinaltumoursandfromnormalcolonicmucosa
AT langmanmjs inhibitionofleucocytemigrationinpatientswithlargeintestinalcancerbyextractspreparedfromlargeintestinaltumoursandfromnormalcolonicmucosa

Ejemplares similares