Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice

AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate acc...

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Autor principal: Ebbesen, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009190/
https://www.ncbi.nlm.nih.gov/pubmed/4413876
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author Ebbesen, P.
author_facet Ebbesen, P.
author_sort Ebbesen, P.
collection PubMed
description AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development. Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.
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spelling pubmed-20091902009-09-10 Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice Ebbesen, P. Br J Cancer Articles AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development. Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran. Nature Publishing Group 1974-07 /pmc/articles/PMC2009190/ /pubmed/4413876 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Ebbesen, P.
Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title_full Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title_fullStr Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title_full_unstemmed Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title_short Influence of Deae-Dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB/c Mice
title_sort influence of deae-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in akr mice and virus induced leukaemia in balb/c mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009190/
https://www.ncbi.nlm.nih.gov/pubmed/4413876
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