Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours

Activities of N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase were measured in rat colonic tumours induced by 1,2-dimethylhydrazine. Tumours varied considerably in their enzyme content, not only from different animals but also from the same animals....

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Detalles Bibliográficos
Autores principales: Mian, N., Cowen, D. M., Nutman, C. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009213/
https://www.ncbi.nlm.nih.gov/pubmed/4451627
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author Mian, N.
Cowen, D. M.
Nutman, C. A.
author_facet Mian, N.
Cowen, D. M.
Nutman, C. A.
author_sort Mian, N.
collection PubMed
description Activities of N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase were measured in rat colonic tumours induced by 1,2-dimethylhydrazine. Tumours varied considerably in their enzyme content, not only from different animals but also from the same animals. Enzymatic heterogeneity among tumours appeared to be related to their site of origin in the colon. The descending colon, which after the DMH treatment showed a significant increase in the levels of glycosidases, also gave rise to a larger number of adenocarcinomata than other parts of the colon. The relative changes in the activities of four glycosidases seemed to show a good correlation. IMAGES:
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spelling pubmed-20092132009-09-10 Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours Mian, N. Cowen, D. M. Nutman, C. A. Br J Cancer Articles Activities of N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase were measured in rat colonic tumours induced by 1,2-dimethylhydrazine. Tumours varied considerably in their enzyme content, not only from different animals but also from the same animals. Enzymatic heterogeneity among tumours appeared to be related to their site of origin in the colon. The descending colon, which after the DMH treatment showed a significant increase in the levels of glycosidases, also gave rise to a larger number of adenocarcinomata than other parts of the colon. The relative changes in the activities of four glycosidases seemed to show a good correlation. IMAGES: Nature Publishing Group 1974-09 /pmc/articles/PMC2009213/ /pubmed/4451627 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Mian, N.
Cowen, D. M.
Nutman, C. A.
Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title_full Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title_fullStr Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title_full_unstemmed Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title_short Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours
title_sort glycosidases heterogeneity among dimethylhydrazine induced rat colonic tumours
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009213/
https://www.ncbi.nlm.nih.gov/pubmed/4451627
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