A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate

Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The depe...

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Detalles Bibliográficos
Autores principales: Davies, R. F., Lee, P. N., Rothwell, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009220/
https://www.ncbi.nlm.nih.gov/pubmed/4425040
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author Davies, R. F.
Lee, P. N.
Rothwell, K.
author_facet Davies, R. F.
Lee, P. N.
Rothwell, K.
author_sort Davies, R. F.
collection PubMed
description Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour incidence on age was adequately described by the Weibull distribution. The relation - ship between dose of smoke condensate and tumour incidence rate was, however, erratic. It was less regular than the simple relationship which has in previous work been found to obtain when the pure carcinogen benzo(a)pyrene is applied to mouse skin.
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spelling pubmed-20092202009-09-10 A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate Davies, R. F. Lee, P. N. Rothwell, K. Br J Cancer Articles Smoke condensate from two types of cigarette, dissolved in two solvents, has been applied regularly to the backs of mice at each of seven different dose levels. Treatment was continued 3 times weekly for up to 110 weeks, by which time 509 of the 1428 treated mice had developed skin tumours. The dependence of tumour incidence on age was adequately described by the Weibull distribution. The relation - ship between dose of smoke condensate and tumour incidence rate was, however, erratic. It was less regular than the simple relationship which has in previous work been found to obtain when the pure carcinogen benzo(a)pyrene is applied to mouse skin. Nature Publishing Group 1974-08 /pmc/articles/PMC2009220/ /pubmed/4425040 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Davies, R. F.
Lee, P. N.
Rothwell, K.
A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title_full A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title_fullStr A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title_full_unstemmed A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title_short A Study of the Dose Response of Mouse Skin to Cigarette Smoke Condensate
title_sort study of the dose response of mouse skin to cigarette smoke condensate
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009220/
https://www.ncbi.nlm.nih.gov/pubmed/4425040
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