The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour

Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proli...

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Autores principales: Rao, K. V. Kesava, Pai, S. R., Bapat, C. V.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009223/
https://www.ncbi.nlm.nih.gov/pubmed/4421360
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author Rao, K. V. Kesava
Pai, S. R.
Bapat, C. V.
author_facet Rao, K. V. Kesava
Pai, S. R.
Bapat, C. V.
author_sort Rao, K. V. Kesava
collection PubMed
description Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that proline inhibits the arginase activity by competing directly at the active site without conformational change. The inhibition may be of regulatory importanec, involving a feedback mechenism in mammary tumours.
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spelling pubmed-20092232009-09-10 The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour Rao, K. V. Kesava Pai, S. R. Bapat, C. V. Br J Cancer Articles Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that proline inhibits the arginase activity by competing directly at the active site without conformational change. The inhibition may be of regulatory importanec, involving a feedback mechenism in mammary tumours. Nature Publishing Group 1974-08 /pmc/articles/PMC2009223/ /pubmed/4421360 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Rao, K. V. Kesava
Pai, S. R.
Bapat, C. V.
The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title_full The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title_fullStr The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title_full_unstemmed The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title_short The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour
title_sort inhibition of arginase by proline in cell-free extracts of mouse mammary tumour
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009223/
https://www.ncbi.nlm.nih.gov/pubmed/4421360
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