Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test

The macrophage migration inhibition test has been used to study the immune responses of guinea-pigs immunized with injections of whole cells of both an allogeneic and a syngeneic hepatoma grown as established cell lines in tissue culture. A clear dose-response relationship between tumour cell concen...

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Detalles Bibliográficos
Autores principales: Desai, H. N., Dale, M. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009249/
https://www.ncbi.nlm.nih.gov/pubmed/4370671
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author Desai, H. N.
Dale, M. M.
author_facet Desai, H. N.
Dale, M. M.
author_sort Desai, H. N.
collection PubMed
description The macrophage migration inhibition test has been used to study the immune responses of guinea-pigs immunized with injections of whole cells of both an allogeneic and a syngeneic hepatoma grown as established cell lines in tissue culture. A clear dose-response relationship between tumour cell concentration and migration inhibition was seen in immunized animals and no significant migration inhibition was seen in control animals. There was no cross reaction between the two tumours used. There was no cross reaction between whole isolated normal liver cells and tumour cells, or between foetal liver cells and tumour cells. Whole isolated liver cells from carbon tetrachloride damaged livers caused some degree of migration inhibition in both normal and immunized guinea-pigs but, taking this into account, they did not appear to cross react with hepatoma cells.
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spelling pubmed-20092492009-09-10 Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test Desai, H. N. Dale, M. M. Br J Cancer Articles The macrophage migration inhibition test has been used to study the immune responses of guinea-pigs immunized with injections of whole cells of both an allogeneic and a syngeneic hepatoma grown as established cell lines in tissue culture. A clear dose-response relationship between tumour cell concentration and migration inhibition was seen in immunized animals and no significant migration inhibition was seen in control animals. There was no cross reaction between the two tumours used. There was no cross reaction between whole isolated normal liver cells and tumour cells, or between foetal liver cells and tumour cells. Whole isolated liver cells from carbon tetrachloride damaged livers caused some degree of migration inhibition in both normal and immunized guinea-pigs but, taking this into account, they did not appear to cross react with hepatoma cells. Nature Publishing Group 1974-08 /pmc/articles/PMC2009249/ /pubmed/4370671 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Desai, H. N.
Dale, M. M.
Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title_full Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title_fullStr Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title_full_unstemmed Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title_short Comparison of Antigenicity of Hepatoma Cells, Normal Liver Cells, Foetal Liver Cells and Chemically Damaged Liver Cells in Guinea-pigs Immunized with Hepatomata using the Macrophage Migration Inhibition Test
title_sort comparison of antigenicity of hepatoma cells, normal liver cells, foetal liver cells and chemically damaged liver cells in guinea-pigs immunized with hepatomata using the macrophage migration inhibition test
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009249/
https://www.ncbi.nlm.nih.gov/pubmed/4370671
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