Studies on the Mechanisms of Chemical Leukaemogenesis

Following a single injection of MNU into “intact” mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days,...

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Detalles Bibliográficos
Autores principales: Dexter, T. M., Schofield, R., Lajtha, L. G., Moore, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009288/
https://www.ncbi.nlm.nih.gov/pubmed/4614855
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author Dexter, T. M.
Schofield, R.
Lajtha, L. G.
Moore, M.
author_facet Dexter, T. M.
Schofield, R.
Lajtha, L. G.
Moore, M.
author_sort Dexter, T. M.
collection PubMed
description Following a single injection of MNU into “intact” mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the “target cells” in MNU leukaemogenesis.
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spelling pubmed-20092882009-09-10 Studies on the Mechanisms of Chemical Leukaemogenesis Dexter, T. M. Schofield, R. Lajtha, L. G. Moore, M. Br J Cancer Articles Following a single injection of MNU into “intact” mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the “target cells” in MNU leukaemogenesis. Nature Publishing Group 1974-10 /pmc/articles/PMC2009288/ /pubmed/4614855 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Dexter, T. M.
Schofield, R.
Lajtha, L. G.
Moore, M.
Studies on the Mechanisms of Chemical Leukaemogenesis
title Studies on the Mechanisms of Chemical Leukaemogenesis
title_full Studies on the Mechanisms of Chemical Leukaemogenesis
title_fullStr Studies on the Mechanisms of Chemical Leukaemogenesis
title_full_unstemmed Studies on the Mechanisms of Chemical Leukaemogenesis
title_short Studies on the Mechanisms of Chemical Leukaemogenesis
title_sort studies on the mechanisms of chemical leukaemogenesis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009288/
https://www.ncbi.nlm.nih.gov/pubmed/4614855
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