On the Theory of Clonal Selection in Carcinogenic Transformation

A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at t...

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Detalles Bibliográficos
Autores principales: Naha, P. M., Ashworth, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009312/
https://www.ncbi.nlm.nih.gov/pubmed/4469197
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author Naha, P. M.
Ashworth, M.
author_facet Naha, P. M.
Ashworth, M.
author_sort Naha, P. M.
collection PubMed
description A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens. IMAGES:
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spelling pubmed-20093122009-09-10 On the Theory of Clonal Selection in Carcinogenic Transformation Naha, P. M. Ashworth, M. Br J Cancer Articles A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens. IMAGES: Nature Publishing Group 1974-11 /pmc/articles/PMC2009312/ /pubmed/4469197 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Naha, P. M.
Ashworth, M.
On the Theory of Clonal Selection in Carcinogenic Transformation
title On the Theory of Clonal Selection in Carcinogenic Transformation
title_full On the Theory of Clonal Selection in Carcinogenic Transformation
title_fullStr On the Theory of Clonal Selection in Carcinogenic Transformation
title_full_unstemmed On the Theory of Clonal Selection in Carcinogenic Transformation
title_short On the Theory of Clonal Selection in Carcinogenic Transformation
title_sort on the theory of clonal selection in carcinogenic transformation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009312/
https://www.ncbi.nlm.nih.gov/pubmed/4469197
work_keys_str_mv AT nahapm onthetheoryofclonalselectionincarcinogenictransformation
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