Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy

A single treatment of adult animals with the potent carcinogen NMU was known to induce tumours in a wide variety of organs, with the notable exception of liver. Administration of NMU after partial hepatectomy gave rise to the first liver cell adenomata ever observed in rats due to this carcinogen. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Craddock, V. M., Frei, J. V.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009335/
https://www.ncbi.nlm.nih.gov/pubmed/4614856
_version_ 1782136094402281472
author Craddock, V. M.
Frei, J. V.
author_facet Craddock, V. M.
Frei, J. V.
author_sort Craddock, V. M.
collection PubMed
description A single treatment of adult animals with the potent carcinogen NMU was known to induce tumours in a wide variety of organs, with the notable exception of liver. Administration of NMU after partial hepatectomy gave rise to the first liver cell adenomata ever observed in rats due to this carcinogen. The tumours were induced when NMU was given during the period of increased DNA synthesis but not when given early in the pre-replicative period. Although tumours were induced in other organs, the incidence of these did not correlate with the timing of NMU administration. It is suggested that replication of damaged DNA may be a relevant event in carcinogenesis. IMAGES:
format Text
id pubmed-2009335
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20093352009-09-10 Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy Craddock, V. M. Frei, J. V. Br J Cancer Articles A single treatment of adult animals with the potent carcinogen NMU was known to induce tumours in a wide variety of organs, with the notable exception of liver. Administration of NMU after partial hepatectomy gave rise to the first liver cell adenomata ever observed in rats due to this carcinogen. The tumours were induced when NMU was given during the period of increased DNA synthesis but not when given early in the pre-replicative period. Although tumours were induced in other organs, the incidence of these did not correlate with the timing of NMU administration. It is suggested that replication of damaged DNA may be a relevant event in carcinogenesis. IMAGES: Nature Publishing Group 1974-12 /pmc/articles/PMC2009335/ /pubmed/4614856 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Craddock, V. M.
Frei, J. V.
Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title_full Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title_fullStr Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title_full_unstemmed Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title_short Induction of Liver Cell Adenomata in the Rat by a Single Treatment with N-Methyl-N-Nitrosourea given at Various Times after Partial Hepatectomy
title_sort induction of liver cell adenomata in the rat by a single treatment with n-methyl-n-nitrosourea given at various times after partial hepatectomy
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009335/
https://www.ncbi.nlm.nih.gov/pubmed/4614856
work_keys_str_mv AT craddockvm inductionoflivercelladenomataintheratbyasingletreatmentwithnmethylnnitrosoureagivenatvarioustimesafterpartialhepatectomy
AT freijv inductionoflivercelladenomataintheratbyasingletreatmentwithnmethylnnitrosoureagivenatvarioustimesafterpartialhepatectomy

Ejemplares similares