Embryonic Antigens and Growth of Murine Fibrosarcomata

The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum. A direct relationship between amount of EA and tumour growing capacity was found. EA were det...

Descripción completa

Detalles Bibliográficos
Autores principales: Ménard, S., Colnaghi, M. L., Porta, G. Della
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1974
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009339/
https://www.ncbi.nlm.nih.gov/pubmed/4447783
_version_ 1782136095327125504
author Ménard, S.
Colnaghi, M. L.
Porta, G. Della
author_facet Ménard, S.
Colnaghi, M. L.
Porta, G. Della
author_sort Ménard, S.
collection PubMed
description The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum. A direct relationship between amount of EA and tumour growing capacity was found. EA were detected also on fast dividing testicular cells. It is suggested that EA expression on tumour cells is related to a cell membrane function controlling mitosis rather than to a function specifically related to the neoplastic status. Tumour take of low doses of 2 EA-bearing sarcomata was found to be enhanced in anti-embryo immune BALB/c mice in comparison with that in normal and anti-fibroblast immune mice.
format Text
id pubmed-2009339
institution National Center for Biotechnology Information
language English
publishDate 1974
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20093392009-09-10 Embryonic Antigens and Growth of Murine Fibrosarcomata Ménard, S. Colnaghi, M. L. Porta, G. Della Br J Cancer Articles The amount of embryonic antigens (EA) was estimated in 13 BALB/c fibrosarcomata by in vitro cell mediated cytotoxicity of anti-embryo spleen cells and by quantitative absorption of an anti-embryo antiserum. A direct relationship between amount of EA and tumour growing capacity was found. EA were detected also on fast dividing testicular cells. It is suggested that EA expression on tumour cells is related to a cell membrane function controlling mitosis rather than to a function specifically related to the neoplastic status. Tumour take of low doses of 2 EA-bearing sarcomata was found to be enhanced in anti-embryo immune BALB/c mice in comparison with that in normal and anti-fibroblast immune mice. Nature Publishing Group 1974-12 /pmc/articles/PMC2009339/ /pubmed/4447783 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Articles
Ménard, S.
Colnaghi, M. L.
Porta, G. Della
Embryonic Antigens and Growth of Murine Fibrosarcomata
title Embryonic Antigens and Growth of Murine Fibrosarcomata
title_full Embryonic Antigens and Growth of Murine Fibrosarcomata
title_fullStr Embryonic Antigens and Growth of Murine Fibrosarcomata
title_full_unstemmed Embryonic Antigens and Growth of Murine Fibrosarcomata
title_short Embryonic Antigens and Growth of Murine Fibrosarcomata
title_sort embryonic antigens and growth of murine fibrosarcomata
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009339/
https://www.ncbi.nlm.nih.gov/pubmed/4447783
work_keys_str_mv AT menards embryonicantigensandgrowthofmurinefibrosarcomata
AT colnaghiml embryonicantigensandgrowthofmurinefibrosarcomata
AT portagdella embryonicantigensandgrowthofmurinefibrosarcomata

Ejemplares similares