The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.

The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lym...

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Detalles Bibliográficos
Autores principales: Franks, C. R., Perkins, F. T., Bshop, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009362/
https://www.ncbi.nlm.nih.gov/pubmed/1080423
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author Franks, C. R.
Perkins, F. T.
Bshop, D.
author_facet Franks, C. R.
Perkins, F. T.
Bshop, D.
author_sort Franks, C. R.
collection PubMed
description The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth.
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spelling pubmed-20093622009-09-10 The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice. Franks, C. R. Perkins, F. T. Bshop, D. Br J Cancer Research Article The effect of exogenous sex hormones on the cell mediated response in male and female mice has been studied by measuring the subcutaneous growth of HeLa tumour nodules and the variation in the total lymphocyte count. It was found that oestrogen treated male and female mice experienced a profound lymphopenia which was vary rapid in onset. Concurrent with the lymphopenia there was prolongation of HeLa tumour nodule growth in female mice, but not in males. A lymphopenia occurred in androgen treated male mice with subsequent prolongation of HeLa tumour nodule growth, and a lymphocytosis in female mice, with reduction of HeLa tumour nodule growth. Nature Publishing Group 1975-01 /pmc/articles/PMC2009362/ /pubmed/1080423 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Franks, C. R.
Perkins, F. T.
Bshop, D.
The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title_full The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title_fullStr The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title_full_unstemmed The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title_short The effect of sex hormones on the growth of HeLa tumour nodules in male and female mice.
title_sort effect of sex hormones on the growth of hela tumour nodules in male and female mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009362/
https://www.ncbi.nlm.nih.gov/pubmed/1080423
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