Adenosine deaminase activity in leukaemia.

Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The me...

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Detalles Bibliográficos
Autores principales: Smyth, J. F., Harrap, K. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009433/
https://www.ncbi.nlm.nih.gov/pubmed/1057444
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author Smyth, J. F.
Harrap, K. R.
author_facet Smyth, J. F.
Harrap, K. R.
author_sort Smyth, J. F.
collection PubMed
description Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed.
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spelling pubmed-20094332009-09-10 Adenosine deaminase activity in leukaemia. Smyth, J. F. Harrap, K. R. Br J Cancer Research Article Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed. Nature Publishing Group 1975-05 /pmc/articles/PMC2009433/ /pubmed/1057444 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Smyth, J. F.
Harrap, K. R.
Adenosine deaminase activity in leukaemia.
title Adenosine deaminase activity in leukaemia.
title_full Adenosine deaminase activity in leukaemia.
title_fullStr Adenosine deaminase activity in leukaemia.
title_full_unstemmed Adenosine deaminase activity in leukaemia.
title_short Adenosine deaminase activity in leukaemia.
title_sort adenosine deaminase activity in leukaemia.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009433/
https://www.ncbi.nlm.nih.gov/pubmed/1057444
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