Differences in proliferative activity of rat and human prostate in culture.

The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat pros...

Descripción completa

Detalles Bibliográficos
Autores principales: Shipman, P. A., Littlewood, V., Riches, A. C., Thomas, G. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009448/
https://www.ncbi.nlm.nih.gov/pubmed/50856
_version_ 1782136117453127680
author Shipman, P. A.
Littlewood, V.
Riches, A. C.
Thomas, G. H.
author_facet Shipman, P. A.
Littlewood, V.
Riches, A. C.
Thomas, G. H.
author_sort Shipman, P. A.
collection PubMed
description The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat prostate to withdrawal of hormone support, and the changes which occurred during culture of BPH were more typical of a repair mechanism to injury than of a castration effect. Cell kinetics was investigated using [125I] iododeoxyuridine and vincristine. Both approaches demonstrated a spontaneous surge in proliferative activity of BPH reaching a peak at about Day 4. In contrast, proliferative activity in rat prostate tended to fall over the period of 2-8 days of culture. The significance of these findings in terms of age linked effects is discussed. IMAGES:
format Text
id pubmed-2009448
institution National Center for Biotechnology Information
language English
publishDate 1975
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20094482009-09-10 Differences in proliferative activity of rat and human prostate in culture. Shipman, P. A. Littlewood, V. Riches, A. C. Thomas, G. H. Br J Cancer Research Article The properties of human benign prostatic hyperplasia (BPH) and rat prostate were compared after culture in the absence of insulin and testosterone. Quantitative methods were used to assess changes in tissue composition and the height of the epithelial cells. BPH appeared less sensitive than rat prostate to withdrawal of hormone support, and the changes which occurred during culture of BPH were more typical of a repair mechanism to injury than of a castration effect. Cell kinetics was investigated using [125I] iododeoxyuridine and vincristine. Both approaches demonstrated a spontaneous surge in proliferative activity of BPH reaching a peak at about Day 4. In contrast, proliferative activity in rat prostate tended to fall over the period of 2-8 days of culture. The significance of these findings in terms of age linked effects is discussed. IMAGES: Nature Publishing Group 1975-05 /pmc/articles/PMC2009448/ /pubmed/50856 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Shipman, P. A.
Littlewood, V.
Riches, A. C.
Thomas, G. H.
Differences in proliferative activity of rat and human prostate in culture.
title Differences in proliferative activity of rat and human prostate in culture.
title_full Differences in proliferative activity of rat and human prostate in culture.
title_fullStr Differences in proliferative activity of rat and human prostate in culture.
title_full_unstemmed Differences in proliferative activity of rat and human prostate in culture.
title_short Differences in proliferative activity of rat and human prostate in culture.
title_sort differences in proliferative activity of rat and human prostate in culture.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009448/
https://www.ncbi.nlm.nih.gov/pubmed/50856
work_keys_str_mv AT shipmanpa differencesinproliferativeactivityofratandhumanprostateinculture
AT littlewoodv differencesinproliferativeactivityofratandhumanprostateinculture
AT richesac differencesinproliferativeactivityofratandhumanprostateinculture
AT thomasgh differencesinproliferativeactivityofratandhumanprostateinculture

Ejemplares similares