Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.

In a previous study of colorectal carcinoma, the LDH isoenzyme pattern was determined in 420 tissue biopsies from 36 surgical specimens. The LDHIV/LDHII ratio was increased in tumour tissue, but in a number of cases increased ratios were found in the morphologically uninvolved tissue as well. This w...

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Detalles Bibliográficos
Autores principales: Langvad, E., Jemec, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009470/
https://www.ncbi.nlm.nih.gov/pubmed/1174443
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author Langvad, E.
Jemec, B.
author_facet Langvad, E.
Jemec, B.
author_sort Langvad, E.
collection PubMed
description In a previous study of colorectal carcinoma, the LDH isoenzyme pattern was determined in 420 tissue biopsies from 36 surgical specimens. The LDHIV/LDHII ratio was increased in tumour tissue, but in a number of cases increased ratios were found in the morphologically uninvolved tissue as well. This was especially pronounced in cases with multiple tumours. The isoenzymatic changes were interpreted therefore as a possible indicator of an early process of malignant conversion. In order to test this hypothesis the original material has been reviewed after observation periods ranging from 5 to 7 years. It appears that the mean LDHVI/LDHII isoenzyme ratio of resection edge biopsies is high (0-92) in patients succumbing with local recurrence, differing significantly (P less than 0-01) from the corresponding mean ratio (0-66) in patients clinically cured.
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spelling pubmed-20094702009-09-10 Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay. Langvad, E. Jemec, B. Br J Cancer Research Article In a previous study of colorectal carcinoma, the LDH isoenzyme pattern was determined in 420 tissue biopsies from 36 surgical specimens. The LDHIV/LDHII ratio was increased in tumour tissue, but in a number of cases increased ratios were found in the morphologically uninvolved tissue as well. This was especially pronounced in cases with multiple tumours. The isoenzymatic changes were interpreted therefore as a possible indicator of an early process of malignant conversion. In order to test this hypothesis the original material has been reviewed after observation periods ranging from 5 to 7 years. It appears that the mean LDHVI/LDHII isoenzyme ratio of resection edge biopsies is high (0-92) in patients succumbing with local recurrence, differing significantly (P less than 0-01) from the corresponding mean ratio (0-66) in patients clinically cured. Nature Publishing Group 1975-06 /pmc/articles/PMC2009470/ /pubmed/1174443 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Langvad, E.
Jemec, B.
Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title_full Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title_fullStr Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title_full_unstemmed Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title_short Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay.
title_sort prediction of local recurrence in colorectal carcinoma: an ldh isoenzymatic assay.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009470/
https://www.ncbi.nlm.nih.gov/pubmed/1174443
work_keys_str_mv AT langvade predictionoflocalrecurrenceincolorectalcarcinomaanldhisoenzymaticassay
AT jemecb predictionoflocalrecurrenceincolorectalcarcinomaanldhisoenzymaticassay

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