Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.

The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts o...

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Detalles Bibliográficos
Autores principales: Griffith, I. P., Crook, N. E., White, D. O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1975
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009475/
https://www.ncbi.nlm.nih.gov/pubmed/1174440
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author Griffith, I. P.
Crook, N. E.
White, D. O.
author_facet Griffith, I. P.
Crook, N. E.
White, D. O.
author_sort Griffith, I. P.
collection PubMed
description The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 cells which had been infected with influenza virus or Semiliki Forest virus (SFV). Partially purified SFV grown in WEHI-11 cells also protected mice from cancer grafts but neither highly purified SFV nor the glycoprotein from the envelope of this virus protected the mice. It is concluded that SFV-induced immunopotentiation against cancer is not due to covalent linkage of tumour specific transplantation antigen (TSTA) to viral envelope protein but more probably is due to the apposition of viral glycoprotein and cellular TSTA in the plasma membrane of the cancer cell. IMAGES:
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spelling pubmed-20094752009-09-10 Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells. Griffith, I. P. Crook, N. E. White, D. O. Br J Cancer Research Article The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 cells which had been infected with influenza virus or Semiliki Forest virus (SFV). Partially purified SFV grown in WEHI-11 cells also protected mice from cancer grafts but neither highly purified SFV nor the glycoprotein from the envelope of this virus protected the mice. It is concluded that SFV-induced immunopotentiation against cancer is not due to covalent linkage of tumour specific transplantation antigen (TSTA) to viral envelope protein but more probably is due to the apposition of viral glycoprotein and cellular TSTA in the plasma membrane of the cancer cell. IMAGES: Nature Publishing Group 1975-06 /pmc/articles/PMC2009475/ /pubmed/1174440 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Griffith, I. P.
Crook, N. E.
White, D. O.
Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title_full Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title_fullStr Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title_full_unstemmed Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title_short Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
title_sort protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009475/
https://www.ncbi.nlm.nih.gov/pubmed/1174440
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