Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.

The concentration of 5-fluorouracil (FU) in thoracic-duct lymph, portal-vein blood and peripheral arterial blood of beagle dogs was greater after administration into the submucosa of the stomach than after the bolus i.v. injection. The concentration of FU in thoracic-duct lymph, portal-vein blood an...

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Detalles Bibliográficos
Autor principal: Thomas, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009494/
https://www.ncbi.nlm.nih.gov/pubmed/619953
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author Thomas, M.
author_facet Thomas, M.
author_sort Thomas, M.
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description The concentration of 5-fluorouracil (FU) in thoracic-duct lymph, portal-vein blood and peripheral arterial blood of beagle dogs was greater after administration into the submucosa of the stomach than after the bolus i.v. injection. The concentration of FU in thoracic-duct lymph, portal-vein blood and arterial blood was least following administration into the lumen of the stomach. The total FU recovered over 6 h from thoracic-duct lymph was compared following the three routes of administration and was found to be greatest following injection into the submucosa of stomach.
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spelling pubmed-20094942009-09-10 Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph. Thomas, M. Br J Cancer Research Article The concentration of 5-fluorouracil (FU) in thoracic-duct lymph, portal-vein blood and peripheral arterial blood of beagle dogs was greater after administration into the submucosa of the stomach than after the bolus i.v. injection. The concentration of FU in thoracic-duct lymph, portal-vein blood and arterial blood was least following administration into the lumen of the stomach. The total FU recovered over 6 h from thoracic-duct lymph was compared following the three routes of administration and was found to be greatest following injection into the submucosa of stomach. Nature Publishing Group 1978-01 /pmc/articles/PMC2009494/ /pubmed/619953 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thomas, M.
Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title_full Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title_fullStr Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title_full_unstemmed Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title_short Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
title_sort effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009494/
https://www.ncbi.nlm.nih.gov/pubmed/619953
work_keys_str_mv AT thomasm effectofrouteofadministrationof5fluorouracilonitsconcentrationinbloodandlymph

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