Glial fibrillary acidic protein in tumours of the nervous system.

Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA....

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Autores principales: Delpech, B., Delpech, A., Vidard, M. N., Girard, N., Tayot, J., Clement, J. C., Creissard, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009497/
https://www.ncbi.nlm.nih.gov/pubmed/339941
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author Delpech, B.
Delpech, A.
Vidard, M. N.
Girard, N.
Tayot, J.
Clement, J. C.
Creissard, P.
author_facet Delpech, B.
Delpech, A.
Vidard, M. N.
Girard, N.
Tayot, J.
Clement, J. C.
Creissard, P.
author_sort Delpech, B.
collection PubMed
description Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical. IMAGES:
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spelling pubmed-20094972009-09-10 Glial fibrillary acidic protein in tumours of the nervous system. Delpech, B. Delpech, A. Vidard, M. N. Girard, N. Tayot, J. Clement, J. C. Creissard, P. Br J Cancer Research Article Glial fibrillary acidic protein (GFA) was assayed in nerve-tumour extracts and located in these tumours by indirect immunofluorescence study. We conclude that GFA is a specific marker of both malignant and normal astrocytes. Non-astrocytic tumours (oligodendroglioma, meningioma) do not contain GFA. Tumours with astrocytic differentiation potential (medulloblastoma) may contain GFA. Comparison of microscopic and GFA assays leads us to conclude that GFA concentration is proportional to the amount of malignant astrocytes in the tumour and inversely proportional to the necrotic area of a tumour. Normal tissue GFA and glioblastoma GFA were found to be immunologically identical. IMAGES: Nature Publishing Group 1978-01 /pmc/articles/PMC2009497/ /pubmed/339941 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Delpech, B.
Delpech, A.
Vidard, M. N.
Girard, N.
Tayot, J.
Clement, J. C.
Creissard, P.
Glial fibrillary acidic protein in tumours of the nervous system.
title Glial fibrillary acidic protein in tumours of the nervous system.
title_full Glial fibrillary acidic protein in tumours of the nervous system.
title_fullStr Glial fibrillary acidic protein in tumours of the nervous system.
title_full_unstemmed Glial fibrillary acidic protein in tumours of the nervous system.
title_short Glial fibrillary acidic protein in tumours of the nervous system.
title_sort glial fibrillary acidic protein in tumours of the nervous system.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009497/
https://www.ncbi.nlm.nih.gov/pubmed/339941
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