Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.

The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinom...

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Autores principales: Bellamy, D., Hinsull, S. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009512/
https://www.ncbi.nlm.nih.gov/pubmed/619960
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author Bellamy, D.
Hinsull, S. M.
author_facet Bellamy, D.
Hinsull, S. M.
author_sort Bellamy, D.
collection PubMed
description The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns.
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spelling pubmed-20095122009-09-10 Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat. Bellamy, D. Hinsull, S. M. Br J Cancer Research Article The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns. Nature Publishing Group 1978-01 /pmc/articles/PMC2009512/ /pubmed/619960 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bellamy, D.
Hinsull, S. M.
Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title_full Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title_fullStr Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title_full_unstemmed Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title_short Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat.
title_sort influence of lodgement site on the proliferation of metastases of walker 256 carcinoma in the rat.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009512/
https://www.ncbi.nlm.nih.gov/pubmed/619960
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