Serial cytogenetic studies of human colonic tumour xenografts.

Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemlin...

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Detalles Bibliográficos
Autores principales: Reeves, B. R., Houghton, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009546/
https://www.ncbi.nlm.nih.gov/pubmed/646932
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author Reeves, B. R.
Houghton, J. A.
author_facet Reeves, B. R.
Houghton, J. A.
author_sort Reeves, B. R.
collection PubMed
description Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed. IMAGES:
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spelling pubmed-20095462009-09-10 Serial cytogenetic studies of human colonic tumour xenografts. Reeves, B. R. Houghton, J. A. Br J Cancer Research Article Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed. IMAGES: Nature Publishing Group 1978-04 /pmc/articles/PMC2009546/ /pubmed/646932 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Reeves, B. R.
Houghton, J. A.
Serial cytogenetic studies of human colonic tumour xenografts.
title Serial cytogenetic studies of human colonic tumour xenografts.
title_full Serial cytogenetic studies of human colonic tumour xenografts.
title_fullStr Serial cytogenetic studies of human colonic tumour xenografts.
title_full_unstemmed Serial cytogenetic studies of human colonic tumour xenografts.
title_short Serial cytogenetic studies of human colonic tumour xenografts.
title_sort serial cytogenetic studies of human colonic tumour xenografts.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009546/
https://www.ncbi.nlm.nih.gov/pubmed/646932
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