Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.

Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or ethylmethylnitrosamine increased the carcinogenic response in the liver of rats as determined by the number of tumours and the number of "focal proliferations" produced. Secondly, in rats given...

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Autores principales: Pound, A. W., McGuire, L. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009562/
https://www.ncbi.nlm.nih.gov/pubmed/646929
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author Pound, A. W.
McGuire, L. J.
author_facet Pound, A. W.
McGuire, L. J.
author_sort Pound, A. W.
collection PubMed
description Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or ethylmethylnitrosamine increased the carcinogenic response in the liver of rats as determined by the number of tumours and the number of "focal proliferations" produced. Secondly, in rats given a single i.p. dose of diethylnitrosamine, 3 partial hepatectomies 5, 10 and 15 weeks after dosing the animals increased the carcinogenic response in the liver. The stimulus of repeated partial hepatectomy therefore appears to act as a "promoting agent" for liver carcinogenesis, that is if the single dose of diethylnitrosamine is regarded as an "initiating agent" in the terms of the two-stage hypothesis. IMAGES:
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spelling pubmed-20095622009-09-10 Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats. Pound, A. W. McGuire, L. J. Br J Cancer Research Article Partial hepatectomy 24 h before a single i.p. dose of dimethylnitrosamine, diethylnitrosamine or ethylmethylnitrosamine increased the carcinogenic response in the liver of rats as determined by the number of tumours and the number of "focal proliferations" produced. Secondly, in rats given a single i.p. dose of diethylnitrosamine, 3 partial hepatectomies 5, 10 and 15 weeks after dosing the animals increased the carcinogenic response in the liver. The stimulus of repeated partial hepatectomy therefore appears to act as a "promoting agent" for liver carcinogenesis, that is if the single dose of diethylnitrosamine is regarded as an "initiating agent" in the terms of the two-stage hypothesis. IMAGES: Nature Publishing Group 1978-04 /pmc/articles/PMC2009562/ /pubmed/646929 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pound, A. W.
McGuire, L. J.
Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title_full Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title_fullStr Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title_full_unstemmed Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title_short Repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
title_sort repeated partial hepatectomy as a promoting stimulus for carcinogenic response of liver to nitrosamines in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009562/
https://www.ncbi.nlm.nih.gov/pubmed/646929
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