Effects of amputation and Corynebacterium parvum on tumour metastases in mice.

The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth....

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Detalles Bibliográficos
Autores principales: Mosley, J. G., Sadler, T. E., Castro, J. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009568/
https://www.ncbi.nlm.nih.gov/pubmed/646927
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author Mosley, J. G.
Sadler, T. E.
Castro, J. E.
author_facet Mosley, J. G.
Sadler, T. E.
Castro, J. E.
author_sort Mosley, J. G.
collection PubMed
description The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth. Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress.
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spelling pubmed-20095682009-09-10 Effects of amputation and Corynebacterium parvum on tumour metastases in mice. Mosley, J. G. Sadler, T. E. Castro, J. E. Br J Cancer Research Article The effects of operation (lower-limb amputation) on the growth of the Lewis lung tumour and its metastases were studied. The role of C. parvum in counteracting these effects was investigated. Anaesthesia alone or with amputation did not affect primary tumour growth. C. parvum depressed this growth. Anaesthesia did not affect the number of pulmonary metastases, but amputation caused a significant increase. C. parvum inhibited metastases and completely counteracted the effects of operation on them. Large doses of cortisone acetate significantly increased metastases but small doses had no effect. Experiments with adrenalectomized mice suggested the effects of operation were due to non-specific stress. Nature Publishing Group 1978-04 /pmc/articles/PMC2009568/ /pubmed/646927 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Mosley, J. G.
Sadler, T. E.
Castro, J. E.
Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title_full Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title_fullStr Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title_full_unstemmed Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title_short Effects of amputation and Corynebacterium parvum on tumour metastases in mice.
title_sort effects of amputation and corynebacterium parvum on tumour metastases in mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009568/
https://www.ncbi.nlm.nih.gov/pubmed/646927
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AT sadlerte effectsofamputationandcorynebacteriumparvumontumourmetastasesinmice
AT castroje effectsofamputationandcorynebacteriumparvumontumourmetastasesinmice

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