Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.

For each of a set of 11 methylcholanthrene-induced sarcomas of B10 mice, we measured the amount of H-2 antigen by absorption of a specific antiserum, and the strength of the tumour-specific transplantation antigen by a transplantation assay, to see whether they are correlated. No obvious correlation...

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Detalles Bibliográficos
Autores principales: Pearson, T., Sikora, K., Lennox, E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009572/
https://www.ncbi.nlm.nih.gov/pubmed/77161
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author Pearson, T.
Sikora, K.
Lennox, E.
author_facet Pearson, T.
Sikora, K.
Lennox, E.
author_sort Pearson, T.
collection PubMed
description For each of a set of 11 methylcholanthrene-induced sarcomas of B10 mice, we measured the amount of H-2 antigen by absorption of a specific antiserum, and the strength of the tumour-specific transplantation antigen by a transplantation assay, to see whether they are correlated. No obvious correlation was seen. We showed that cell suspensions of tumours taken directly from the animal are contaminated by host cells which make a substantial contribution in H-2 assays. Since this contamination was lost after several passages in vitro, the amount of H-2 on tumour cells was assayed only after such passages.
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spelling pubmed-20095722009-09-10 Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas. Pearson, T. Sikora, K. Lennox, E. Br J Cancer Research Article For each of a set of 11 methylcholanthrene-induced sarcomas of B10 mice, we measured the amount of H-2 antigen by absorption of a specific antiserum, and the strength of the tumour-specific transplantation antigen by a transplantation assay, to see whether they are correlated. No obvious correlation was seen. We showed that cell suspensions of tumours taken directly from the animal are contaminated by host cells which make a substantial contribution in H-2 assays. Since this contamination was lost after several passages in vitro, the amount of H-2 on tumour cells was assayed only after such passages. Nature Publishing Group 1978-04 /pmc/articles/PMC2009572/ /pubmed/77161 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pearson, T.
Sikora, K.
Lennox, E.
Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title_full Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title_fullStr Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title_full_unstemmed Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title_short Measurement of H-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
title_sort measurement of h-2 antigen and immunogenicity of methylcholanthrene-induced murine sarcomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009572/
https://www.ncbi.nlm.nih.gov/pubmed/77161
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