Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.

The effect of serial passage in immune-deprived mice on certain biological and biochemical parameters has been studied in a series of 6 human colorectal tumour xenografts. Histological integrity is maintained for up to 10 serial passages, together with production of epithelial mucins and carcinoembr...

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Detalles Bibliográficos
Autores principales: Houghton, J. A., Taylor, D. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009589/
https://www.ncbi.nlm.nih.gov/pubmed/629858
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author Houghton, J. A.
Taylor, D. M.
author_facet Houghton, J. A.
Taylor, D. M.
author_sort Houghton, J. A.
collection PubMed
description The effect of serial passage in immune-deprived mice on certain biological and biochemical parameters has been studied in a series of 6 human colorectal tumour xenografts. Histological integrity is maintained for up to 10 serial passages, together with production of epithelial mucins and carcinoembryonic antigen. Passaged tumours retain human lactate dehydrogenase and glucose-6-phosphate dehydrogenase isoenzyme patterns and a human chromosome constitution. The induction of a murine tumour has been identified in this system, and the importance of routine checks for the presence of human tissue during serial passage is stressed. IMAGES:
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spelling pubmed-20095892009-09-10 Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice. Houghton, J. A. Taylor, D. M. Br J Cancer Research Article The effect of serial passage in immune-deprived mice on certain biological and biochemical parameters has been studied in a series of 6 human colorectal tumour xenografts. Histological integrity is maintained for up to 10 serial passages, together with production of epithelial mucins and carcinoembryonic antigen. Passaged tumours retain human lactate dehydrogenase and glucose-6-phosphate dehydrogenase isoenzyme patterns and a human chromosome constitution. The induction of a murine tumour has been identified in this system, and the importance of routine checks for the presence of human tissue during serial passage is stressed. IMAGES: Nature Publishing Group 1978-02 /pmc/articles/PMC2009589/ /pubmed/629858 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Houghton, J. A.
Taylor, D. M.
Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title_full Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title_fullStr Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title_full_unstemmed Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title_short Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
title_sort maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009589/
https://www.ncbi.nlm.nih.gov/pubmed/629858
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