Malignant neoplasms in rats fed lasiocarpine.

Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinoma...

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Detalles Bibliográficos
Autores principales: Rao, M. S., Reddy, J. K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009590/
https://www.ncbi.nlm.nih.gov/pubmed/204322
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author Rao, M. S.
Reddy, J. K.
author_facet Rao, M. S.
Reddy, J. K.
author_sort Rao, M. S.
collection PubMed
description Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations. IMAGES:
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spelling pubmed-20095902009-09-10 Malignant neoplasms in rats fed lasiocarpine. Rao, M. S. Reddy, J. K. Br J Cancer Research Article Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations. IMAGES: Nature Publishing Group 1978-02 /pmc/articles/PMC2009590/ /pubmed/204322 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rao, M. S.
Reddy, J. K.
Malignant neoplasms in rats fed lasiocarpine.
title Malignant neoplasms in rats fed lasiocarpine.
title_full Malignant neoplasms in rats fed lasiocarpine.
title_fullStr Malignant neoplasms in rats fed lasiocarpine.
title_full_unstemmed Malignant neoplasms in rats fed lasiocarpine.
title_short Malignant neoplasms in rats fed lasiocarpine.
title_sort malignant neoplasms in rats fed lasiocarpine.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009590/
https://www.ncbi.nlm.nih.gov/pubmed/204322
work_keys_str_mv AT raoms malignantneoplasmsinratsfedlasiocarpine
AT reddyjk malignantneoplasmsinratsfedlasiocarpine

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