Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.

Adherent, predominantly phagocytic mononuclear cells from various rat tissues express spontaneous cytoxicity against diverse target cells in vitro. The extent to which cytotoxicity was expressed by effector cells depended on the age of donors. Cytolytic effector-cell capacity was already fully devel...

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Detalles Bibliográficos
Autor principal: Keller, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009632/
https://www.ncbi.nlm.nih.gov/pubmed/656303
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author Keller, R.
author_facet Keller, R.
author_sort Keller, R.
collection PubMed
description Adherent, predominantly phagocytic mononuclear cells from various rat tissues express spontaneous cytoxicity against diverse target cells in vitro. The extent to which cytotoxicity was expressed by effector cells depended on the age of donors. Cytolytic effector-cell capacity was already fully developed a few days after birth, and persisted over many months, but was clearly reduced in senescence. Similarly, the ability to intensify natural cytotoxicity by peptone in vivo was already fully manifested in the newborn, but was significantly diminished in old rats.
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spelling pubmed-20096322009-09-10 Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages. Keller, R. Br J Cancer Research Article Adherent, predominantly phagocytic mononuclear cells from various rat tissues express spontaneous cytoxicity against diverse target cells in vitro. The extent to which cytotoxicity was expressed by effector cells depended on the age of donors. Cytolytic effector-cell capacity was already fully developed a few days after birth, and persisted over many months, but was clearly reduced in senescence. Similarly, the ability to intensify natural cytotoxicity by peptone in vivo was already fully manifested in the newborn, but was significantly diminished in old rats. Nature Publishing Group 1978-05 /pmc/articles/PMC2009632/ /pubmed/656303 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Keller, R.
Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title_full Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title_fullStr Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title_full_unstemmed Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title_short Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.
title_sort macrophage-mediated natural cytotoxicity against various target cells in vitro. ii. macrophages from rats of different ages.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009632/
https://www.ncbi.nlm.nih.gov/pubmed/656303
work_keys_str_mv AT kellerr macrophagemediatednaturalcytotoxicityagainstvarioustargetcellsinvitroiimacrophagesfromratsofdifferentages

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