Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.

Over the past 70 years many experiments have been designed to promote tumour growth. These studies were all carried out in allogeneic tumour systems or by artificially influencing the immunization process. In the present study, the growth of syngeneic mammary tumour cells was enhanced by prior immun...

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Detalles Bibliográficos
Autores principales: Laursen, M. L., Laursen, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009641/
https://www.ncbi.nlm.nih.gov/pubmed/678425
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author Laursen, M. L.
Laursen, K.
author_facet Laursen, M. L.
Laursen, K.
author_sort Laursen, M. L.
collection PubMed
description Over the past 70 years many experiments have been designed to promote tumour growth. These studies were all carried out in allogeneic tumour systems or by artificially influencing the immunization process. In the present study, the growth of syngeneic mammary tumour cells was enhanced by prior immunization via the intracaecal route. Such induced enhancement could be transferred to untreated animals by serum or by spleen cells. Tumour growth was also enhanced in another syngeneic system by immunization via the intestinal route with frozen-thawed ascites tumour cells. The result is in direct contrast to that obtained by similar immunization with live cells, which affords protection against a later challenge.
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spelling pubmed-20096412009-09-10 Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route. Laursen, M. L. Laursen, K. Br J Cancer Research Article Over the past 70 years many experiments have been designed to promote tumour growth. These studies were all carried out in allogeneic tumour systems or by artificially influencing the immunization process. In the present study, the growth of syngeneic mammary tumour cells was enhanced by prior immunization via the intracaecal route. Such induced enhancement could be transferred to untreated animals by serum or by spleen cells. Tumour growth was also enhanced in another syngeneic system by immunization via the intestinal route with frozen-thawed ascites tumour cells. The result is in direct contrast to that obtained by similar immunization with live cells, which affords protection against a later challenge. Nature Publishing Group 1978-06 /pmc/articles/PMC2009641/ /pubmed/678425 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Laursen, M. L.
Laursen, K.
Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title_full Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title_fullStr Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title_full_unstemmed Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title_short Enhancement of tumour growth in two syngeneic C3H murine systems by immunization via the intracaecal route.
title_sort enhancement of tumour growth in two syngeneic c3h murine systems by immunization via the intracaecal route.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009641/
https://www.ncbi.nlm.nih.gov/pubmed/678425
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