Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.

The blood flow of tumours growing in rat mammary glands previously exposed to 1500 R X-rays was 52% that of same-sized tumours in unirradiated host tissue. About 2 months after irradiation, the blood flow of the mammary gland was raised and that of the skin was unchanged, compared with the correspon...

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Autores principales: Jirtle, R., Rankin, J. H., Clifton, K. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009642/
https://www.ncbi.nlm.nih.gov/pubmed/678424
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author Jirtle, R.
Rankin, J. H.
Clifton, K. H.
author_facet Jirtle, R.
Rankin, J. H.
Clifton, K. H.
author_sort Jirtle, R.
collection PubMed
description The blood flow of tumours growing in rat mammary glands previously exposed to 1500 R X-rays was 52% that of same-sized tumours in unirradiated host tissue. About 2 months after irradiation, the blood flow of the mammary gland was raised and that of the skin was unchanged, compared with the corresponding unirradiated tissue. Tumours growing in preirradiated and unirradiated mammary glands responded similarly to bolus injections of noradrenaline, angiotensin II, and isoprenaline. The responses of the irradiated tissues to these drugs were, however, not always the same as those of the corresponding unirradiated tissues. Exposure of the lungs to approximately 1500 R X-rays made the animals uniquely sensitive to bolus injections of noradrenaline and angiotensin II.
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spelling pubmed-20096422009-09-10 Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs. Jirtle, R. Rankin, J. H. Clifton, K. H. Br J Cancer Research Article The blood flow of tumours growing in rat mammary glands previously exposed to 1500 R X-rays was 52% that of same-sized tumours in unirradiated host tissue. About 2 months after irradiation, the blood flow of the mammary gland was raised and that of the skin was unchanged, compared with the corresponding unirradiated tissue. Tumours growing in preirradiated and unirradiated mammary glands responded similarly to bolus injections of noradrenaline, angiotensin II, and isoprenaline. The responses of the irradiated tissues to these drugs were, however, not always the same as those of the corresponding unirradiated tissues. Exposure of the lungs to approximately 1500 R X-rays made the animals uniquely sensitive to bolus injections of noradrenaline and angiotensin II. Nature Publishing Group 1978-06 /pmc/articles/PMC2009642/ /pubmed/678424 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Jirtle, R.
Rankin, J. H.
Clifton, K. H.
Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title_full Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title_fullStr Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title_full_unstemmed Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title_short Effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
title_sort effect of x-irradiation of tumour bed on tumour blood flow and vascular response to drugs.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009642/
https://www.ncbi.nlm.nih.gov/pubmed/678424
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AT cliftonkh effectofxirradiationoftumourbedontumourbloodflowandvascularresponsetodrugs

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