Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.

Aprotinin was bound and endocytosed by Landschütz ascites carcinoma (LAC) cells in vitro. Addition of the antiprotease to cultures of these cells led to a dose-dependent growth-inhibitory and cytotoxic effect. In mice inoculated with LAC cells and treated with aprotinin there was a transient reducti...

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Autores principales: Thomson, A. W., Tweedie, D. J., Pugh-Humphreys, R. G., Arthur, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009670/
https://www.ncbi.nlm.nih.gov/pubmed/308375
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author Thomson, A. W.
Tweedie, D. J.
Pugh-Humphreys, R. G.
Arthur, M.
author_facet Thomson, A. W.
Tweedie, D. J.
Pugh-Humphreys, R. G.
Arthur, M.
author_sort Thomson, A. W.
collection PubMed
description Aprotinin was bound and endocytosed by Landschütz ascites carcinoma (LAC) cells in vitro. Addition of the antiprotease to cultures of these cells led to a dose-dependent growth-inhibitory and cytotoxic effect. In mice inoculated with LAC cells and treated with aprotinin there was a transient reduction in both the number and concentration of recovered ascites cells during the early phase of tumour growth. This was accompanied by a temporary increase in the proportion of peritoneal phagocytes (mononuclear phagocytes and polymorphonuclear leucocytes) relative to carcinoma cells. However, the number and concentration of ascites cells eventually achieved was comparable in saline and aprotinin-treated animals. IMAGES:
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spelling pubmed-20096702009-09-10 Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo. Thomson, A. W. Tweedie, D. J. Pugh-Humphreys, R. G. Arthur, M. Br J Cancer Research Article Aprotinin was bound and endocytosed by Landschütz ascites carcinoma (LAC) cells in vitro. Addition of the antiprotease to cultures of these cells led to a dose-dependent growth-inhibitory and cytotoxic effect. In mice inoculated with LAC cells and treated with aprotinin there was a transient reduction in both the number and concentration of recovered ascites cells during the early phase of tumour growth. This was accompanied by a temporary increase in the proportion of peritoneal phagocytes (mononuclear phagocytes and polymorphonuclear leucocytes) relative to carcinoma cells. However, the number and concentration of ascites cells eventually achieved was comparable in saline and aprotinin-treated animals. IMAGES: Nature Publishing Group 1978-07 /pmc/articles/PMC2009670/ /pubmed/308375 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thomson, A. W.
Tweedie, D. J.
Pugh-Humphreys, R. G.
Arthur, M.
Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title_full Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title_fullStr Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title_full_unstemmed Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title_short Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.
title_sort endocytosis of the antiprotease aprotinin by landschütz ascites carcinoma cells and its effects in vitro and in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009670/
https://www.ncbi.nlm.nih.gov/pubmed/308375
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