Radiation leukaemogenesis: is virus really necessary?

Generalized lymphosarcomatosis (leukaemia) of non-thymic type occurs in mice bearing 90Sr or 239Pu or 226Ra. Tumours passaged from such mice have been tested for tumour-associated transplantation antigens that could provoke a protective immunity which would be expected if such antigens were determin...

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Detalles Bibliográficos
Autores principales: Loutit, J. F., Ash, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1978
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009681/
https://www.ncbi.nlm.nih.gov/pubmed/581177
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author Loutit, J. F.
Ash, P. J.
author_facet Loutit, J. F.
Ash, P. J.
author_sort Loutit, J. F.
collection PubMed
description Generalized lymphosarcomatosis (leukaemia) of non-thymic type occurs in mice bearing 90Sr or 239Pu or 226Ra. Tumours passaged from such mice have been tested for tumour-associated transplantation antigens that could provoke a protective immunity which would be expected if such antigens were determined by virus activated by the irradiation. Sub-threshold doses of living syngeneic tumour, large doses of living allogeneic tumour and large doses of killed syngeneic tumour were without protective effect. This suggests that viruses observed electron micrographically in such tumours are passengers and not causative. IMAGES:
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spelling pubmed-20096812009-09-10 Radiation leukaemogenesis: is virus really necessary? Loutit, J. F. Ash, P. J. Br J Cancer Research Article Generalized lymphosarcomatosis (leukaemia) of non-thymic type occurs in mice bearing 90Sr or 239Pu or 226Ra. Tumours passaged from such mice have been tested for tumour-associated transplantation antigens that could provoke a protective immunity which would be expected if such antigens were determined by virus activated by the irradiation. Sub-threshold doses of living syngeneic tumour, large doses of living allogeneic tumour and large doses of killed syngeneic tumour were without protective effect. This suggests that viruses observed electron micrographically in such tumours are passengers and not causative. IMAGES: Nature Publishing Group 1978-07 /pmc/articles/PMC2009681/ /pubmed/581177 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Loutit, J. F.
Ash, P. J.
Radiation leukaemogenesis: is virus really necessary?
title Radiation leukaemogenesis: is virus really necessary?
title_full Radiation leukaemogenesis: is virus really necessary?
title_fullStr Radiation leukaemogenesis: is virus really necessary?
title_full_unstemmed Radiation leukaemogenesis: is virus really necessary?
title_short Radiation leukaemogenesis: is virus really necessary?
title_sort radiation leukaemogenesis: is virus really necessary?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2009681/
https://www.ncbi.nlm.nih.gov/pubmed/581177
work_keys_str_mv AT loutitjf radiationleukaemogenesisisvirusreallynecessary
AT ashpj radiationleukaemogenesisisvirusreallynecessary

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